This book covers the latest findings of a wide variety of viral, prokaryotic and eukaryotic macromolecular protein complexes and builds upon the solid macromolecular foundations established by previous volumes of the Subcellular Biochemistry series. Thus, an almost encyclopaedic coverage of the broad field of protein complex structure and function has been established.

The 17 interesting chapters included in this book have been organised into four sections: Soluble Protein Complexes, Membrane Protein Complexes, Fibrous Protein Complexes and Viral Protein Complexes. Significant topics present here are: Fatty Acid Synthase, the Fork Protection Complex, Ribonucleotide Reductase, the Kinetochore, G proteins, the FtsEX Complex, the Kainate Receptor, the Photosystem I-antenna, the Mycobacterial Arabinofuranosyltransferases, the the Bacterial Flagellum, the Actomyosin Complex, Motile Cilia, SLS Collagen Polymorphic Structures, and the Reovirus Capsid and Polymerase. Up-dates/expansion of chapter topics present in earlier volumes are now included in chapters here, e.g., those on Ferritin-like proteins and the Multi-tRNA Synthetase.

The book is richly illustrated throughout, which is the result of an impressive integration of structural data from X-ray crystallography with that from cryo-electron microscopy. Functional aspects of protein-protein interactions are also given a high priority.

Autorentext

J. Robin Harris is a retired structural biologist and electron microscopist. He is an Honorary Professor of the University of Mainz, Germany, where he worked with the group of Professor Juergen Markl, in the Institute of Zoology. Since taking retirement, Robin continued part-time research for a number of years at the University of Newcastle, UK, and acted as an Editor of the Elsevier journal Micron and as Series Editor of the long-standing Springer book series Subcellular Biochemistry.Jon Marles-Wright obtained his PhD in structural biology from the University of Oxford, where he focused on understanding how human immune receptors interact with their targets. For his post-doctoral training he moved to the University of Newcastle, where his research focus moved to bacterial cell biology. In 2012 Jon was appointed to a two-year career development fellowship at the University of Newcastle where he developed his interest in the structural basis of metabolic compartmentalization within bacteria. This was followed by nearly four years at The University of Edinburgh as a Chancellor's Fellow in the Institute of Structural and Molecular Biology and Centre for Systems and Synthetic Biology. Jon is currently a Senior Lecturer in Microbial Biotechnology in the School of Biology at Newcastle University.

Inhalt

Macromolecular Protein Complexes IV: Structure and Function

Harris and Marles-Wright

Contents list

Soluble Protein Complexes

1 Fatty Acid Synthase: Structure, Function, and Regulation

Aybeg N. Günenc, Benjamin Graf, Holger Stark, Ashwin Chari

2 ATP-binding cassette transporters: Snap-on complexes?

Iqra Younus, Sofia Kochkina1, Ceri Choi, Wenjuan Sun and Robert C. Ford

3 The Fork Protection Complex: A regulatory hub at the head of the replisome Daniel B. Grabarczyk

4 Ferritin-like Proteins: A Conserved Core for a Myriad of Enzyme Complexes Rahul Banerjee, Vivek Srinivas and Hugo Lebrette

5 Still no rest for the reductases: Ribonucleotide reductase (RNR) Structure and Function - an update

Marcus J. C. Long, Phillippe Ly, and Yimon Aye

6 Structure and Dynamics of the Human Multi-tRNA Synthetase Complex

Myung Hee Kim, Beom Sik Kang

7 On the regulation of mitosis by the kinetochore, a macromolecular complex

and organising hub of eukaryotic organisms

Victor M. Bolanos-Garcia

Membrane Protein Complexes

8 The conformational dynamics of heterotrimeric G proteins during GPCR-mediated activation

Donghoon Ahn, Ka Young Chung

9 Regulation of Lytic Machineries by the FtsEX Complex in the Bacterial Divisome

Martín Alcorlo, Siseth Martínez-Caballero, Rafael Molina and Juan A. Hermoso

10 Structure, Function, and Regulation of the Kainate Receptor

Surbhi Dhingra, Juhi Yadav and Janesh Kumar

11 Structure, function and variations of the photosystem I-antenna supercomplex from different photosynthetic organisms

Jian-Ren Shen

12 Structure and Function of Mycobacterial Arabinofuranosyltransferases

Yong Zi Tan, Filippo Mancia

Fibrous Protein Complexes 13 Structure and assembly of the bacterial flagellum Natalie S. Al-Otaibi and Julien R. C. Bergeron

14 Actomyosin Complex

Ian Pepper and Vitold E. Galkin

15 Structure of motile cilia

Takashi Ishikawa

16 Segment-Long-Spacing (SLS) and the Polymorphic Structures of Fibrillar Collagen

Yujia Xu and Michele Kirchner

Virus Protein Complexes

17 Viral Capsid and Polymerase in Reoviridae

Hongrong Liu and Lingpeng Cheng