Computational Neurogenetic Modeling Integrating Bioinformatics and Neuroscience Data, Information and Knowledge via Computational Intelligence

Lubica Benuskova and Nikola Kasabov

With the presence of a great amount of both brain and gene data related to brain functions and diseases, it is required that sophisticated computational neurogenetic models be created to facilitate new discoveries that will help researchers in understanding the brain in its complex interaction between genetic and neuronal processes. Initial steps in this direction are underway, using the methods of computational intelligence to integrate knowledge, data and information from genetics, bioinfomatics and neuroscience.

Computational Neurogenetic Modeling offers the knowledge base for creating such models covering the areas of neuroscience, genetics, bioinformatics and computational intelligence. This multidisciplinary background is then integrated into a generic computational neurogenetic modeling methodology. computational neurogenetic models offer vital applications for learning and memory, brain aging and Alzheimer's disease, Parkinson's disease, mental retardation, schizophrenia and epilepsy.

Key Topics Include:

Brain Information Processing

Methods of Computational Intelligence, Including:

• Artificial Neural Networks

• Evolutionary Computation

• Evolving ConnectionistSystems

  Gene Information Processing

  Methodologies for Building Computational Neurogenetic Models

  Applications of CNGM for modeling brain functions and diseases Computational Neurogenetic Modeling is essential reading for postgraduate students and researchers in the areas of information sciences, artificial intelligence, neurosciences, bioinformatics and cognitive sciences. This volume is structured so that every chapter can be used as a reading material for research oriented courses at a postgraduate level.

  About the Authors:

  Lubica Benuskova is currently Senior Research Fellow at the Knowledge Engineering & Discovery Research Institute (KEDRI, www.kedri.info), Auckland University of Technology (AUT) in Auckland, New Zealand. She is also Associate Professor of Applied Informatics at the Faculty of Mathematics, Physics and Informatics at Comenius (Komensky) University in Bratislava, Slovakia. Her research interests are in the areas of computational neuroscience, cognitive science, neuroinformatics, computer and information sciences.

  Nikola Kasabov is the Founding Director and Chief Scientist of KEDRI, and a Professor and Chair of Knowledge Engineering at the School of Computer and Information Sciences at AUT. He is a leading expert in computational intelligence and knowledge engineering and has published more than 400 papers, books and patents in the areas of neural and hybrid intelligent systems, bioinformatics and neuroinformatics, speech-, image and multimodal information processing. He is a Fellow of the Royal Society of New Zealand, Senior Member of IEEE, Vice President of the International Neural Network Society and a Past President of the Asia-Pacific Neural Network Assembly.

  Klappentext

Computational Neurogenetic Modeling Integrating Bioinformatics and Neuroscience Data, Information and Knowledge via Computational Intelligence

Lubica Benuskova and Nikola Kasabov

With the presence of a great amount of both brain and gene data related to brain functions and diseases, it is required that sophisticated computational neurogenetic models be created to facilitate new discoveries that will help researchers in understanding the brain in its complex interaction between genetic and neuronal processes. Initial steps in this direction are underway, using the methods of computational intelligence to integrate knowledge, data and information from genetics, bioinfomatics and neuroscience.

Computational Neurogenetic Modeling offers the knowledge base for creating such models covering the areas of neuroscience, genetics, bioinformatics and computational intelligence. This multidisciplinary background is then integrated into a generic computational neurogenetic modeling methodology. computational neurogenetic models offer vital applications for learning and memory, brain aging and Alzheimer's disease, Parkinson's disease, mental retardation, schizophrenia and epilepsy.

Key Topics Include:

• Brain Information Processing

• Methods of Computational Intelligence, Including:

  • Artificial Neural Networks
  • Evolutionary Computation
  • Evolving ConnectionistSystems

• Gene Information Processing

• Methodologies for Building Computational Neurogenetic Models

• Applications of CNGM for modeling brain functions and diseases Computational Neurogenetic Modeling is essential reading for postgraduate students and researchers in the areas of information sciences, artificial intelligence, neurosciences, bioinformatics and cognitive sciences. This volume is structured so that every chapter can be used as a reading material for research oriented courses at a postgraduate level.

  About the Authors:

  Lubica Benuskova is currently Senior Research Fellow at the Knowledge Engineering & Discovery Research Institute (KEDRI, www.kedri.info), Auckland University of Technology (AUT) in Auckland, New Zealand. She is also Associate Professor of Applied Informatics at the Faculty of Mathematics, Physics and Informatics at Comenius (Komensky) University in Bratislava, Slovakia. Her research interests are in the areas of computational neuroscience, cognitive science, neuroinformatics, computer and information sciences.

  Nikola Kasabov is the Founding Director and Chief Scientist of KEDRI, and a Professor and Chair of Knowledge Engineering at the School of Computer and Information Sciences at AUT. He is a leading expert in computational intelligence and knowledge engineering and has published more than 400 papers, books and patents in the areas of neural and hybrid intelligent systems, bioinformatics and neuroinformatics, speech-, image and multimodal information processing. He is a Fellow of the Royal Society of New Zealand, Senior Member of IEEE, Vice President of the International Neural Network Society and a Past President of the Asia-Pacific Neural Network Assembly.

  Zusammenfassung

Computational Neurogenetic Modeling is a student text, introducing the scope and problems of a new scientific discipline - Computational Neurogenetic Modeling (CNGM). CNGM is concerned with the study and development of dynamic neuronal models for modeling brain functions with respect to genes and dynamic interactions between genes. These include neural network models and their integration with gene network models. This new area brings together knowledge from various scientific disciplines, such as computer and information science, neuroscience and cognitive science, genetics and molecular biology, as well as engineering.

Inhalt
Computational Neurogenetic Modeling (CNGM): A Brief Introduction.- Organization and Functions of the Brain.- Neuro-Information Processing in the Brain.- Artificial Neural Networks (ANN).- Evolving Connectionist Systems (ECOS).- Evolutionary Computation for Model and Feature Optimization.- Gene/Protein Interactions Modeling Gene Regulatory Networks (GRN).- CNGM as Integration of GPRN, ANN and Evolving Processes.- Application of CNGM to Learning and Memory.- Applications of CNGM and Future Development.