Lipid-mediated Protein Signaling

Lipids are no longer seen as molecules that only provide membrane structure and organization. Due to their amphipathic nature, lipids are localized both on the surface and internally in membranes in the cell, and at these locations, trigger signaling pathways by interacting with soluble proteins, typically through lipid-interacting domains and motifs. More importantly, interconversion of lipid species in these compartments is fundamental, not only by sustaining signaling but also by contributing to signaling pathways that link protein receptors with intracellular effectors. With contributions from eleven leading research teams, this book updates the most recent findings associated with lipid-mediated cell signaling in mammals and plants. Contributors give comprehensive overviews of the physiological role of sphingolipids and phospholipids and how they undergo synthesis and turnover. Emphasis on the structural aspects of protein-lipid interactions is compiled in several chapters with great detail, whereas fully described mechanisms of lipid-mediated membrane targeting and insertion are considered in others. Authors also discuss models and techniques used to characterize lipid-mediated membrane binding of proteins. In addition, several chapters highlight the correlation of abnormal intracellular levels of lipids with human diseases, thus, making this book a valuable resource for biochemists, biophysicists, cell biologists, and clinical scientists with interest in lipid-mediated signaling pathways.

Zusammenfassung
This book provides the most updated information of how membrane lipids mediate protein signaling from studies carried out in animal and plant cells. Also, there are some chapters that go beyond and expand these studies of protein-lipid interactions at the structural level. The book begins with a literature review from investigations associated to sphingolipids, followed by studies that describe the role of phosphoinositides in signaling and closing with the function of other key lipids in signaling at the plasma membrane and intracellular organelles.

Inhalt

Sphingomyelin and its role in cellular signaling.- The driving force of alpha-synuclein insertion and amyloid channel formation in the plasma membrane of neural cells: key role of ganglioside- and cholesterol-binding domains.- The enigmatic role of sulfatides: new insights into cellular functions and mechanisms of protein recognition.- Phosphoinositides and PDZ Domain Scaffolds.- PtdIns(4)P signalling and recognition systems.- PtdIns(4,5)P2-Mediated Cell Signaling: Emerging Principles and PTEN as a Paradigm for Regulatory Mechanism.- Role of Phosphatidylinositol 3,4,5-trisphosphate in Cell Signaling.- The Role of Phosphoinositides and Inositol Phosphates in Plant Cell Signaling.- Phosphatidic Acid-Mediated Signaling.- Phosphatidylserine-mediated cellular signaling.- Cardiolipin-mediated cellular signaling.