Increasing survival figures and the use of more intense combined treatment regimens in modern oncology have raised the problem of late therapeutic sequelae in long-term survivors after cancer. Recent scientific approaches to late sequelae concentrate on the evaluation of subclinical changes with sophisticated functional measurements and experimental investigation of the underlying pathophysiological mechanisms. The objective of the book is to bring together these recent clinical and experimental data from different medical disciplines to give an overview of the most relevant problems of late sequelae. In clinical practice the book may help regarding estimation of risks, selection of diagnostic methods, and estimation of the prognosis of late sequelae.

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1 Individual Variation of Radio- and Chemosensitivity.- 1.1 Impact of Endogenous and Exogenous Factors on Radiation Sequelae.- 1.2 Endogenous and Exogenous Factors Modifying Chemosensitivity to Cytostatic Drugs.- 2 Neurotoxicity.- 2.1 Radiation-Induced Injury of the Central Nervous System.- 2.2 Cytostatic-Induced Central Nervous System Abnormalities.- 2.3 Radiation Myelopathy.- 2.4 Acute and Late Toxicity on Peripheral Nerves After Radiotherapy.- 2.5 Acute and Late Toxicity on Peripheral Nerves After Chemotherapy - A Review.- 2.6 Endocrine Dysfunction After Brain Tumor Therapy in Children.- 2.7 Endocrine Dysfunction in Adults After Radiotherapy for Pituitary Adenomas and Suprasellar Tumors.- 2.8 Late Sequelae Affecting the Ear.- 2.9 Ototoxicity in Pediatric Oncology.- 3 Skin and Mucosal Toxicity.- 3.1 Biological Basis for Skin and Mucosal Toxicity.- 3.2 Radiation-Induced Fibrosis: Experimental Studies.- 3.3 Lymphedema of the Arm After Treatment of Breast Cancer.- 3.4 Skin and Mucosal Damage After Radiotherapy for Head and Neck Tumors.- 3.5 Mucosal Toxicity After Radiochemotherapy.- 3.6 Complications of the Small Intestine and the Pancreas After Intraoperative Radiotherapy.- 3.7 Skin Toxicity.- 4 Lung Toxicity.- 4.1 Radiation Pneumopathy - Experimental and Clinical Data.- 4.2 Lung Toxicity of Chemotherapeutic Agents.- 4.3 Differential Diagnosis of Treatment Sequelae in the Lung.- 5 Cardiotoxicity.- 5.1 Evaluation of Late Cardiotoxicity by Pulsed Doppler Echocardiography in Patients Treated for Hodgkin's Disease.- 5.2 Anthracycline-Induced Cardiotoxicity in Children: Pathophysiology and Prevention.- 5.3 Radiation-Induced Cardiotoxicity: Experimental Data.- 5.4 Cardiotoxicity After Megavoltage Irradiation and Chemotherapy for Hodgkin's Disease with Special Emphasis on Coronary Heart Disease Mortality - The Freiburg Experience 1940-1992.- 5.5 Cardiac Morbidity and Mortality Followig Radiotherapy.- 6 Nephrotoxicity.- 6.1 Nephrotoxicity of Ifosfamide in Children.- 6.2 Radiation Nephritis.- 7 Gonadal Toxicity.- 7.1 Long-Term Gonadal Dysfunction and Its Impact on Bone Mineralization in Patients Following COPP/ABVD Chemotherapy for Hodgkin's Disease.- 7.2 Gonadal Dysfunction After Radiotherapy.- 8 Disturbances of Sceletal Growth.- 8.1 Dose-Time Considerations for Skeletal Growth Disturbances After Radiotherapy.- 8.2 Disturbances in Growth of Bone, Muscle, and Fat Tissue Following Irradiation in Childhood.- 8.3 Growth Failure Secondary to Radiotherapy of Brain Tumors in Childhood.- 9 Cancerogenesis.- 9.1 Experiments on the Carcinogenic Potential of Antineoplastic Agents.- 9.2 Secondary Malignancies Following Cytotoxic Chemotherapy.- 9.3 Secondary Malignancies After Radiotherapy.- List of Contributors.