This book deals with the new method of laser-driven acceleration for application to radiation biophysics and medicine. It provides multidisciplinary contributions from world leading scientist in order to assess the state of the art of innovative tools for radiation biology research and medical applications of ionizing radiation. The book contains insightful contributions on highly topical aspects of spatio-temporal radiation biophysics, evolving over several orders of magnitude, typically from femtosecond and sub-micrometer scales. Particular attention is devoted to the emerging technology of laser-driven particle accelerators and their applicatio to spatio-temporal radiation biology and medical physics, customization of non-conventional and selective radiotherapy and optimized radioprotection protocols.

Autorentext

Antonio Giulietti is a physicist operating at INO (National Institute of Optics, Italy). He has been CNR Research Director and Head of the Unit "Adriano Gozzini" of INO. He founded ILIL (Intense Laser Irradiation Laboratory) in the CNR Campus of Pisa which has been operating for more than 20 years with scientific output and international collaboration making ILIL a primary reference in the domain of laser-plasmas. AG is author of more than 200 papers published on international refereed journals, mainly in the field of laser and plasma physics, plasma instabilities relevant to Inertial Fusion, radiation from plasmas, laser-driven particle acceleration and their biomedical potential. AG has organized and chaired a large number of international conferences on these topics. He is member of the International Advisory Board of the International Conference on High Energy Density Science, annually held in Yokohama. His research group has been supported by CNR, Italian Ministry of Education, Italian Ministry of Health, European Union, Extreme light Infrastructure (ELI), CEA (France), JSPS (Japan). AG has been very active in teaching and tutoring students and young scientists. Young scientists trained in the AG' lab are today Professors or Researchers in prestigious Universities or Research Institutions, including Universities of Pisa, Siena, Milano, Bordeaux, Oxford, Belfast, Ecole Polytechnique in Palaiseau, CEA-Saclay, BMI-Berlin, Rutherford Appleton Laboratory. In the last ten years 2006-2015 AG devoted most of his work at studying possible medical uses of laser-driven particle accelerators. Experiments performed in Pisa and at CEA-Saclay led to the discovery of a high efficiency acceleration regime allowing the production of electron bunches whose charge and kinetic energy are suitable for radiotherapy. Those electrons were also used to drive a gamma sources and produce photo-activation, so opening a perspective of interest for nuclear medicine. In the meantime AG promoted R&D studies to achieve a practical usability of laser-driven accelerators in radiobiology and clinics, also in collaboration with CEA-Saclay and University of Osaka. In this framework he recently published (2015) a review paper on Laser-Plasma Particle Sources for Biology and Medicine.

Inhalt
From the Contents: Part I Laser driven particle acceleration: From experiments to devices.- Ultra-intense lasers and particle acceleration: past, present and future.- Part II Biophysical studies with laser driven particle sources.- Part III Synchrotron, ion accelerator and microbeam.- Synchrotron source: dosimetry and pre-clinical trials.