The physiological and pathological significance of the kallikrein-kinin system was recently explored extensively, resulting in a rapid accumulation of information regarding their potential importance. This publication provides an integrated picture of the latest information on the kallikrein­ kinin system. It contains contributions from morphologists, geneticists, biochemists, pharmacologists, physiologists, and clinicians. The Fifth International Kinin Congress (Nov. 29-Dec. 3, 1987) provided a forum for the exchange of information and ideas on the kallikrein-kinin system. The participation of more than 350 scientists from 23 countries reflects the widespread interest and international scope of research activity in the physiological and pathological functions of the kallikrein-kinin system. A total of 275 papers including posters were presented, attesting to the unquestioned success of this Congress. These proceedings, in two volumes, contain the collective studies presented, studies of high scientific standard that provoked stimulating and fruitful discussions. Also included in these volumes are the two plenary lectures presented by Dr. H.A. Margolius (USA) and Dr. S. Nakanishi (Japan). During the last decade our knowledge of the role of the kallikrein­ kinin system in health and disease has been greatly advanced by the develop­ ment of antagonists to bradykinin and the introduction to clinical practice of converting enzyme inhibitors. Symposia on converting enzyme and on recent advances in research on the kallikrein-kinin system are included in the proceedings.

Inhalt

• Part A.- Tissue Kallikreins and Kinins: Roles in Human Disease and Target for New Drug Development.- Control of Kininogen Gene Expression.- Angiotensin I Converting Enzyme Inhibitors, Kinin and Prostaglandin Systems.- Biochemistry of Renin.- Angiotensin I Converting Enzyme.- Pharmocokinetics of Angiotensin Converting Enzyme Inhibitors in Plasma and Tissue Using Radioinhibitor Binding and Displacement Assays.- Role of the Endogenous Angiotensin II in the Antihypertensive Effect of MK 421 in Rats Made Hypertensive by Norepinephrine or Vasopressin.- Significance of Kallikrein-Kinin and Renin-Angiotensin Systems in the Hypotensive Mechanism of Angiotensin-I Converting Enzyme Inhibitors in Essential Hypertensives.- Clinical Usefulness of Low-Dose Captopril on Mild to Moderate Essential Hypertension.- Therapeutic Regime of Enalapril Maleate in Japan.- Beneficial and Adverse Effects of Angiotensin Converting Enzyme Inhibitors.- Tissue Kallikrein and its Functional Roles - Kidney and Other Organs -.- Structural Analysis of a Rat Renal Kallikrein Gene.- Development of Competitive Antagonists of Bradykinin.- Physiological Role of Renal Kallikrein-Kinin System in Human.- Effects of Kinin on Electrolytes Transport and Regulation of Kininase Activity in Distal Nephron Segments of the Rat.- Diversity of Kinin Effects on Transporting Epithelia.- Patho-Physiology of Kallikrein-Kinin System - Inflammation, Allergy and Others -.- The Role of T-Kininogen and H and L Kininogens in Health and Disease.- Recent Studies on the Role of Kinins in Inflammatory Diseases of Human Airways.- The Kallikrein-Kinin System in Inflammation.- A Significant Role of Plasma Kallikrein-Kinin System in Plasma Exudation of Rat Carrageenin-Induced Pleurisy.- Role of High Molecular Weight (HMW)-Kininogen in Inflammatory Exudation: Evidence with the Studies of the HMW-Kininogen Deficient Rat.- Kallikrein-Kinin System in Infectious Diseases.- Kininogen in Tumor-Bearing Mice.- Angiotensin Converting Enzyme and Inhibitors.- Regional Distribution of Angiotensin Converting Enzyme in the Rat Kidney.- Immunohistologic Characterization of Angiotensin Converting Enzyme in the Human Kidney Using Monoclonal and Polyclonal Antibodies.- Effects of Mineralocorticoid on Kininase Activity Along the Distal Nephron Segments of the Rat.- Selective Expression of Des-Arg9-BK Sensitive (B1) Receptors In Vivo and In Vitro by Angiotensin Converting Enzyme Inhibitors.- Demonstration of In Vivo Effects of Ace Inhibitors by the Use of Autoregressive Modelling.- Contribution of Kinin System to the Antihypertensive Action of Angiotensin Converting Enzyme Inhibitors.- Increased Insulin-Responsiveness by Ace-Inhibition in Non-Insulin Dependent Diabetes Mellitus.- Kinins, Related Peptides and Arachidonic Acid Metabolites.- A New Structural Class of Biologically Active Peptide in Non-Mammals.- Vasoactive Peptides from the VESPA Orientalis Hornet Venom.- Bradykinin Analogs Induce Histamine Release from Human Skin Mast Cells.- Role of Cardiovascular Phospholipase A2 and C in the Development of DOCA-Salt Hypertensive Rats.- Neutrophil Producing Capacity of 5-Lipoxygenase Metabolites of Arachidonic Acid After Major Surgery.- The Mechanism of the Stimulatory Effect of Kallikrein on Prostacyclin Production in Vascular Endothelial Cells.- The Effect of Bradykinin and its Fragments on the Arachidonate Cascade of Brain Microvessels.- Mechanism of Bradykinin-Induced Nociceptive Response.- Antagonism of the Algesic Action of Bradykinin on the Human Blister Base.- Kallikrein-Kinin in Renal Function.- Effects of Sodium Intake on Urinary Excretion and Renal Content of Bradykinin and its Metabolites in Rats.- Kallikrein Release by Rat Kidney Slices: Effect of Norepinephrine.- Relationship Between ANP, Cyclic GMP and Tissue Kallikrein Following Saline Infusion in Healthy Volunteers.- Bradykinin (BK) Enhances Diuresis and Natriuresis in Saline Volume-Expanded Dogs.- Kininases.- Kininase Activities in the Human Pituitary Gland.- Purification of Human Seminal Plasma Kininase II Using Affinity Chromatography.- Dipeptidyl(Amino)Peptidase IV and Post Proline Cleaving Enzyme in Cultured Endothelial and Smooth Muscle Cells.- Isolation and Study of the Properties of Kininase from the Venom of Spider Latrodectus Tredecimguttatus.- Post Synthetic Modification of CK-MM by Kininase I.- Structure of Human Carboxypeptidase in (Kininase I).- The Mechanism of Degradation of Bradykinin (LYSYL-Bradykinin) in Human Serum.- Kininogens.- Rocket Immunoassay of High and Low Molecular Weight Kininogens in Human Plasma.- High Molecular Weight Kininogen Binds to Neutrophils.- Inhibition of Thrombin-Induced Platelet Aggregation by High Molecular Weight Kininogen.- Characterization of Kinins Released from Human Kininogens by Human Urinary Kallikrein.- Ornitho-kininogen and Ornitho-kinin: Isolation, Characterization, and Chemical Structure.- Inflammation and Kallikrein-Kinin.- The Kallikrein-Kininogen System in Myocardial Infarction.- The Pathophysiological Role of Kinin and Chemical Mediators on Experimental Allergic Rhinitis.- Release of Kinin and Other Chemical Mediators After Antigenic Stimulation in Allergic Rhinitis Patients.- Akikatsu Kataura, Kazuaki Shimamoto, and Osamu Iimura Kallikrein Activity in Saliva of Patients with Inflammatory and Hyperplastic Diseases of the Oral Mucous Membrane.- The Effect of Cyclosporine on Urinary Kallikrein Excretion in Patients with Rheumatoid Arthritis.- The Influence of Oxindanac on Kallikrein Metabolism.- Kinin Receptors and Antagonists.- Basic Pharmacology of Kinis: Pharmacologic Receptors and Other Mechanisms.- An Iodinatable Photoaffinity Probe Based on the Structure of Kallidin.- Specific Binding Sites for Bradykinin and its Degradation Process in Cultured Rat Vascular Smooth Muscle Cells.- Kinin Receptors on Epithelial Cells and Smooth Muscle of the Trachea.- Different Involvement of Endothelium-Derived Relaxing Factor and Prostacyclin in Vasodilator Response to Bradykinin in Isolated Dog Blood Vessels.- The Effect of a Bradykinin Antagonist on Vasodilatation in the Cat and Rabbit.- Effects on Blood Pressure of Intracerebroventricular Administration of a Kinin Antagonist.- Plasma Kallikrein-Kinin and Related Systems.- Hageman Factor Dependent Kinin Generation System in Guinea Pig Skin: Extravascular Localization of the Components, and Pr…