Scientists from 25 countries came together at the Hyatt Regency Hotel on October 21-25, 1984, for the 4th International Kinin Congress in the beautiful city of Savannah, Georgia. Many of the delegates enjoyed southern hospitality for the first time. The friendly city with its streets lined with the Live Oak Tree (symbol of the Congress), the balmy weather, and the excellent facilities of the hotel set the stage for scientific events and exchange that proved so successful. The organ­ ization of the meeting was the result of many hours, days and weeks of effort by many, including from Augusta Drs. James H. Sutherland, John Catravas, William Davis, Jr. , and Hiroshi Okamoto; and from Charleston, SC, Julie Chao, Ronald Mayfield and Donald Miller. Special thanks go to Ms. Cher Cornett of the Department of Medical Illustration at the Medical College of Georgia for her talent in the design of the logo, as well as the graphics of the program and abstracts. We are indeed indebted to Dr. Paul Brucker, Director of the Division of Health Communi­ cations at the Medical College of Georgia, for his considerable aid in spending time with us to arrange the programming format and continuity. Ms. Sandra Usry provided very excellent and devoted secretarial help for several years while the Congress was in the making.

Inhalt

• Part A.- Tissue Kininogenases.- The Varied Localization and Functional Significance of Kallikrein-Like Enzymes in Salivary Glands, Pancreas, Colon, Sex Glands and Spermatozoa, Including Evidence for the Presence of Nerve Growth Factor (NGF) in Bull Sperm Acrosome.- Kininogenase from Rat Vascular Tissue.- Intracellular and Intercellular Distributions of Acid Kininogenases in Spleen.- Localization of Kallikreins in the Human Parotid and Gland in the Human Kidney: A Comparative Study of Immunohistochemistry and Enzyme Histochemistry.- Studies on Carbohydrate Structure and Immunological Properties of Human Urinary Kallikreins.- Initial Observations of a Kallikrein-Like Enzyme Associated with the Plasma Membranes of Rat Adipocytes.- Bile Acids and the Intestinal Kallikrein-Kinin System.- Kininogens.- T-Kinin and T-Kininogen - An Historical Overview.- Increased Plasma Level of T-Kininogen in Rats Treated with Freund's Adjuvant.- Isolation and Properties of Two Rat Plasma T-Kininogens.- Characterization of Kininogen Deficiency of Brown Norway Rat Mutant Katholiek Strain.- Amino Acid Sequence of the Light Chain of Human Low Molecular Mass Kininogen.- Limited Proteolysis of HMW Kininogen by Plasma Kallikrein in Man- Evidence for a Processing Mechanism Different from the Bovine System.- Interaction of Human Low Molecular Weight Kininogen with Human Mast Cell Tryptase.- Independent Consumption of High and Low Molecular Weight Kininogens In Vivo.- Urinary Kininogen: A Possible Regulator of Kinin Formation in Normal Individuals and Subjects with Essential Hypertension, End-Stage Renal and Liver Disease.- Monoclonal Antibodies to Rat Plasma Kininogen.- Hydrolysis of Rat High Molecular Weight Kininogen by Purified Rat Urinary Kallikrein: Identification of Bradykinin as the Kinin Formed.- Reduced or Unchanged Cofactor Function of Human High Molecular Weight Kininogen Induced by Human Plasma Kallikrein.- Studies on the Antigenic Determinants of Human Low Molecular Weight Kininogen.- Kininogen by the SRI Method in Human Serum During an Acute Phase Inflammatory Reaction.- Kininogen as a Pregnancy-Associated Plasma Protein.- Hemodynamics of the Isolated Perfused Rat Kidney in the Absence and Presence of Kallikrein Substrate.- Tissue Kallikreins, Kinins, and Kininases.- Active Kallikrein, Preprokallikrein, and Kallikrein-Inhibitor Complex.- Characterization of Rat Kallikrein-Like Multigene Family and Its Expression in the Submandibular Gland.- Processing of Apolipoprotein B-100 of Human Plasma Low Density Lipoproteins by Tissue and Plasma Kallikreins.- Transporting Epithelia as Targets for Kinin Effects.- Purification and Partial Characterization of Cat Colon and Submandibular Gland Kallikreins.- Purification and Partial Characterization of Cat Pancreatic and Urinary Kallikreins - Comparison with Other Cat Tissue Kallikreins and Related Proteases.- The Liver is the Main Organ to Clear Plasma and Tissue Kallikreins from Rat Plasma, In Vivo.- Receptor-Mediated Clearance of Tissue Kallikreins by Rat Liver.- Tissue Kallikreins and Related Enzymes: Characterization by Model Oligopeptides.- Release of Kallikrein and Tonin from the Rat Submandibular Gland.- Effect of Sodium Restriction and Corticosteroids on Glandular Kallikrein in Plasma and in the Submandibular Gland.- Kallikrein and Kinins Independently Stimulate Renin Release from Isolated Rat Glomeruli.- Regulation of Parotid Kallikrein Secretion-Role of the Alpha2- and Beta-Adrenergic System.- Effect of Furosemide on the Rat Submandibular Gland Kallikrein Secretion.- Individual Reaction Steps in the Release of Kallidin From Kininogen by Tissue Kallikrein.- The Tissue Kallikrein-Kinin System in Human Seminal Plasma - Biochemical and Functional Aspects.- New Synthetic Substrate for Kallikrein and Its Application.- Plasma Half-Live and Organ Uptake Ratio of Radiolabeled Glandular Kallikrein in Control and Nephrectomized Rats.- Hormonal Regulation of Glandular Kallikrein Activity and Its Inhibitor in Human Plasma.- A Comparative Study of Prokal1ikreins and Kallikreins from Rat Pancreatic Tissue and Juice.- An Inactive Form of Kallikrein in Human Urine.- Purification of Inactive Kallikrein from Rat Urine.- Release of Tissue Kallikrein from the Isolated Perfused Kidney.- Analytical Study of Kallikrein and Kallikrein-Like Esterase Activity in Subfractions from Rat Kidney Cortex Microsomes and Isolated Subcellular Membranes.- Endogenous Kallikrein Inhibitor in Rat Kidney Cortex-Effect of Glucocorticoid Administration.- Metabolism of Bradykinin in Isolated Perfused Rat Kidney Measurement of Kininase Activity in Perfusate and Urine.- Functional Significance of the Subunits of Carboxypeptidase N (Kininase I).- Kininase One-An'-A-Half: The Newest Member of the Kininase Family.- Partial Characterization of a Liver Serine-Peptidase from Different Species which Inactivates Bradykinin.- Vascular, Post Proline Cleaving Enzyme: Metabolism of Vasoactive Peptides.- Synthetic Inhibitors of Carboxypeptides N.- Angiotensin Converting Enzyme Inhibitors.- Carboxyalkyl Peptide Inhibitors of Kininase II: Chiral Synthesis.- Slow Tight Binding Inhibitors of Angiotensin Converting Enzyme.- Radiolabelled Substrates for Angiotensin Converting Enzyme.- Aggregate Anaphylaxis and Carboxypeptidase N.- Michaelis-Menten Kinetics of Pulmonary Endothelial Angiotensin Converting Enzyme in the Conscious Rabbit.- In Vivo Determinations of Ki Values for Angiotensin Converting Enzyme Inhibitors.- Rat Testicular Angiotensin I Converting Enzyme: Purification and Comparison with Rat Pulmonary Enzyme.- Kininase II of Human Seminal Fluid: Kinetics and Inhibition.- Investigations on the Functional Role of Angiotensin Converting Enzyme (ACE) in Human Seminal Plasma.- Biological Regulation of Testicular Angiotensin I-Converting Enzyme.- Role of Kininase II (ACE; E.C.3.4.15.1) in the Regulation of Renin Secretion.- The Effect of Alphanapthylthiourea (ANTU)-Induced Acute Injury on Lung Binding of Antibody to Angiotensin Converting Enzyme (ACE).- Isolation and Sequencing of an Active-Site Peptide from Angiotensin I-Converting Enzyme.- Value of Determination of Kininase II in Bronchoalveolar Lavage Fluid.- Evidence for a Potent Angiotensin I Degrading Enzyme Different from Angiotensin I Converting Enzyme in Rat Vascular Tissues.- Receptors and Antagonists of Kinins.- Bradykinin Competitive Antagonists for Classical Kinin Systems.- Smooth Muscle Selectivity in Bradykinin Analogs with Multiple D-Amino Acid Substitutions.- Kinins, Receptors, Antagonists.- Effects of Kinins on the Isolated Perfused Rat Kidney and Evidence for the Presence of Renal B1~ Receptors.…