Increasing interest in the immunology of mucosal surfaces is obvious from the number of publications in scientific journals and from the frequency of national and international symposia devoted to this subject. Particularly encouraging are the large numbers of young investigators who have chosen to work in this area of theoretical immunology with profound practical implications. The two volumes represented here are the result of an International Congress Of Mucosal Immunology held at the Niagara Falls Convention Center and the Niagara Falls Hilton on June 29 - July 3, 1986. This satellite meeting of the International Congress of Immunology placed emphasis on all aspects of the Mucosal Immune System. This included the regulation of differentiation of mucosal lymphocytes, mucosa-associated lymphoreticular tissue and lymphocyte homing, the immunology of mucosa­ associated tissues and glands, effector functions in mucosal immunity, and the effects of environmental antigens on the immune response, all of which are included in Volume I. The second volume has emphasized studies of the immune response and effector functions, IgA biosynthesis and transport, IgA proteases and effector functions, developmental aspects and immunodeficiency, the immunopathology of IgA and mucosal immunoprophylaxis. A total of 218 papers are included in these two volumes and a comparison to past meetings held at four to five year intervals indicates the explosive growth of mucosal immunology.

Inhalt

Introductory Address.- Perturbations in Peyer's Patch B Cell Populations Indicative of Priming for a Secretory IgA Response.- Session I: Regulation of Differentiation of Mucosal Lymphocytes.- Rabbit IgA Heavy Chain Genes: Cloning and in vitro Expression.- Immunoglobulin Gene Expression in Wasted Mice.- Molecular Aspects of T Cell Regulation of B Cell Isotype Differentiation.- Switch T Cell Line, ST, Induces an Ig Class Switch in Surface Isotype.- Regulatory T Cell Networks in the Secretory Immune System.- Novel Regulatory Mechanisms of IgA Synthesis: Respective Roles of Neuropeptides and Cells of the Anti-Suppressor Circuit.- Fc-Specific Suppressor T Cells.- Isotype-Specific Immunoglobulin Binding Factors of IgA and IgE.- Isotype Specific Immunoregulation: Role of Fc?R+ T Cells and IBF? in IgA Responses.- Autoreactive T Cells Regulating B Cell Growth and Differentiation in Murine Peyer's Patches.- T Cell Clones That Help IgA Responses.- Antigen-Specific Helper T Cells in the Intestine: Origin and Migration.- Limiting Dilution Analysis of Functional T Cells in the Gut Mucosa.- Isotype-Specific Immunoregulation: T Contrasuppressor Cells Protect IgA Responses in Oral Tolerance.- Regulatory T Cells in the Galt.- T Dependent Induction of an IgA and IgM Anti-Polysaccharide Response.- A Predominant Idiotype in the Gut-Associated Lymphoid Tissue.- Isolation of Peyer's Patch T Cell Subsets Involved in Isotype Specific Immunoregulation.- Expression of Substance P and Somatostatin Receptors on a T Helper Cell Line.- N-Terminal Ten Amino Acid Sequence Determined for B-Cell Differentiation Factor Derived from Rabbit Breast Milk Cell Supernatant.- A Novel Pre-B Cell Precursor: Phenotypic Characterization and Differentiation Induction by Dendritic Cell-T Cell Mixtures.- The Role of Epithelial Cells as Accessory Cells.- Antigen Presentation by Gut Epithelial Cells: Secretion by Rat Enterocytes of a Factor with IL-1-Like Activity.- Syngeneic and Allogeneic T Cell Reactivity to I-Region Determinants on Rat Intestinal Epithelial Cells.- Differential Tissue Distribution of HLA-DR, -DP and -DQ Antigens.- Mucosal T Lymphocytes in Human Colonic Schistosomiasis: Relationship to MHC Antigens.- Session II: Mucosa Associated Lymphoreticular Tissue and Lymphocyte Homing.- Canine Peyer's Patches: Macroscopic, Light Microscopic, Scanning Electron Microscopic and Immunohistochemical Investigations.- The Role of Peyer's Patches in Intestinal Humoral Immune Responses is Limited to Memory Formation.- Murine Peyer's Patches are Capable of Generating a Cytotoxic T Cell (CTL) Response to Nominal Antigens.- Immunocytochemical Studies of the Vascular Endothelial Cells in Human Peyer's Patches and Solitary Lymphoid Follicles.- Migration of Peyer's Patch IgA Precursor Cells.- Migration of Individual Lymphocytes into Peyer's Patches in vivo.- Chemotaxis as a Mechanism for Recruitment of Mucosal Plasma Cell Precursors.- Properties of Human B Cells Terminating in Normal Gut-Associated Lymphoid Tissue, Including Peyer's Patches.- Session III: Immunology of Mucosa-Associated Tissues and Glands.- Subclass Distribution OF IgG- and IgA-Producing Cells in Secretory Tissues and Alterations Related to Gut Diseases.- Altered Patterns of Secretion of IgA and IgG Subclasses by Ulcerative Colitis and Crohn's Disease Intestinal Mononuclear Cells.- Immunohistochemical Analysis of Human Inflammatory Appendix.- Characterization and Mitogenic Responsiveness of Murine Mammary Gland Mononuclear Cells.- Clearance, Localization and Catabolism of Intravenously Administered Protein Antigens in Lactating Mice.- Specific Antibacterial Antibody-Producing Cells in Human Nasal Mucosa.- Incidence and Distribution of Immunocytes in the Murine Oral Mucosa.- Characterization of Lymphoid Cells from the Human Fallopian Tube Mucosa.- Ultrastructural Localization of IgA and IgG in Uterine Epithelial Cells Following Estradiol Administration.- Origin of IgA and IgG Antibodies in the Female Reproductive Tract: Regulation of the Genital Response by Estradiol.- Cholecystokinin-Induced Release of IgA Antibodies in Rat Intestine.- A Model for Paneth Cell Study: Tissue Culture of the Hyperplastic Paneth Cell Population of Rabbit Thiry-Vella Ileal Loops.- Antigen Induced Gastrin Release: An Immunologic Mechanism of Gastric Antral Mucosa.- Immunocytochemical Markers for Human Milk Macrophages and Epithelial Cells.- Pleomorphic Adenomas Contain a Keratin-Negative Population of HLA-DR-Positive Dendritic Cells.- Discordance between IgA B Cell Precursors and the Secretion of IgA Antibody to Bacterial Polysaccharides.- Session IV: Effector Functions in Mucosal Immunity.- Cytotoxic Lymphocytes in Human Intestinal Mucosa.- T Cell and Mononuclear Phagocyte Populations of the Human Small and Large Intestine.- Functional and Phenotypic Analysis of Lymphocytes Isolated from Human Intestinal Mucosa.- Monoclonal Antibodies Specific for Human and Rat Intestinal Lymphocytes.- Isolation and Characterization of Rabbit Ileal Lamina Propria Mononuclear Cells.- Rabbit Ileal Lamina Propria (LP) Lymphocytes Give Poor Blastogenic Responses to KLH Immunization and Concanavalin A Mitogenesis.- T Cell-Driven Appearance of Mononuclear Cells, Mast Cells and Goblet Cells in the Respiratory Tract.- Antibacterial Activity of Lymphocytes Armed with IgA.- Antibacterial Activity against Streptococcus Pneumoniae by Mouse Lung Lymphocytes.- Potentiation of Rat Colon Intraepithelial Lymphocyte (IEL) Natural Killer (NK) Activity with Indomethacin.- Natural Killer (NK) Cell Activity against Enteric Murine Coronavirus Mediated by Intestinal Leukocytes.- Inhibition of Natural Killer (NK) Activity by Human Colostral and Serum IgA.- HSV-1 Infected Oral Epithelial Cells are Targets for Natural Killer Cells.- Involvement of Human Immunodeficiency Virus (HIV) in Gingiva of Patients with AIDS.- RFc Alpha-Bearing Cells and IgA-Mediated Phagocytosis in the Mouse Oral Mucosa.- In vitro Effects of IgA on Human Polymorphonuclear Leukocytes.- Presence of Fc Receptors for IgA on Rat Alveolar Macrophages but Not Peritoneal Macrophages.- Enumeration, Receptor Expression and Phagocytic Capabilities of Eosinophils of Human Colon Mucosa.- Cofactor Requirements for Expression of Lactoferrin Bactericidal Activity on Enteric Bacteria.- Interaction of Antisera to the Secretory Component with Fc?R.- Mast Cell Pleomorphism: Properties of Intestinal Mast Cells.- Intestinal Mucosal Mast Cells in Rats with Graft-Versus-Hos…