This book presents the selected research works from the 16th International Conference on Industrial Engineering and Industrial Management in 2022. The conference was promoted by ADINGOR (Asociación para el Desarrollo de la Ingeniería de Organización), organized by Ingenium Research Group at Universidad de Castilla-La Mancha, Spain, and it took place on July 7th and 8th, 2022, in Toledo, Spain. The book highlights some of the latest research advances and cutting-edge analyses of real-world case studies on Industrial Engineering and Industrial Management from a wide range of international contexts. It also identifies business applications and the latest findings and innovations in Operations Management and in Decision Sciences.