This volume presents papers presented at CISIS 2019 and ICEUTE 2019, held in the beautiful and historic city of Seville (Spain) in May 2019. The 12th CISIS 2019 conference offered a meeting opportunity for academic and industry-related researchers form the various communities of computational intelligence, information security and data mining, and the need for intelligent, flexible behaviour by large, complex systems, especially in mission-critical domains, was the catalyst and the aggregation stimulus for the event. The book covers current topics such as cryptographic and data analytics solutions to fulfil least minimum privilege and endorse least minimum effort in information systems. The book also includes 15 papers from the 10th ICEUTE 2019, covering topics like new approaches to assess competencies and innovation in computer science education.