The volume includes a collection of peer-reviewed contributions from among those presented at the FNE, the main conference organized every two years by the Mexican Statistical Society (AME), and the 2020 AME Virtual Meeting. Statistical research in Latin America is prolific and research networks span both within and outside the region. As much of the work is typically carried out and published in Spanish, a large portion of the interested public is denied access to interesting findings, and the goal of this volume is therefore to provide access to selected works from Mexican collaborators and their international research networks to a wider audience. It may be especially attractive to academics interested in the latest methodological advances, while professionals from other disciplines may also find value in these new tools for data analysis. In 2021, the conference broadly focused on the interdisciplinary aspects of Statistics.