The three-volume set CCIS 2603, 2604 and 2605 constitutes the refereed proceedings of the 16th International Conference on Intelligent Systems, INTELS 2024, held in Moscow, Russia, during December 2-4, 2024.

The 72 papers included in these proceedings were carefully reviewed and selected from 140 submissions. They focus on areas of intelligent systems and artificial intelligence and their application to sustainable development and new challenges to the society.