This book aims to systemically summarize the key findings about Innate lymphoid cells (ILCs) and present the consensus of current views and prospective. ILCs are a class of newly recognized immune cells which play an instructive role in shaping immunity in physiological and pathological conditions. This book discusses the differentiation of ILC, the relation of ILCs with respiratory function, inflammation in the gut, skin disorders, cancer, neurobiology and microbes. The knowledge included in this book is valuable for both basic immunologists and clinicians in understanding the heterogenetic immune responses in disease and health.

Autorentext

Dr. Xiao-Hong Sun holds the Lew and Myra Chair for biomedical Research of the Program in arthritis and Clinical immunology, Oklahoma Medical Research Foundation. She is also an Adjunct professor in the Department of Microbiology and Immunology and Department of Cell Biology of the University of Oklahoma Health Sciences Center. She is an Associate Editor of "BMC Immunology" and member of board of directors of the Ray Wu Memorial Fund. Prof. Sun's research focuses on regulatory mechanisms of innate lymphoid cells. She has published more than 60 research articles on international peer-reviewed journals.

Inhalt

Overview.- ILC differentiation from progenitors in the bone marrow.- ILC differentiation from in the thymus.- NK and ILC1.- ILC2 and respritory function.- ILC3 and inflammation in the gut.- ILCs in skin disorders.- ILCs in cancer.- ILCs and neurobiology.- ILCs and microbials.- Prospectives.