This book constitutes the thoroughly refereed post-conference proceedings of the Second International Conference on Industrial Networks and Intelligent Systems, INISCOM 2016 held in Leicester, UK, October 31 - November 1, 2016. The 15 revised full papers carefully reviewed and selected from 22 submissions. The papers cover topics on industrial networks and applications, intelligent systems, information processing and data analysis, hardware and software design and development, security and privacy.