The book you are just going to read represents the greater part of the papers presented at the International Conference on Industrial and En­ vironmental Xenobiotics, held in Prague, 1980, and some contributions by those who could not come. The first aim of the meeting was to fol­ low the tradition set up by the first conference in 1977. Again, we in­ vited biochemists, pharmacologists, and toxicologists from both East and West, who were involved in the study of disposition, biotransforma­ tion, and toxicity of important kinds of industrial and environmental pollutants, to promote the exchange of ideas and opinions on priorities in this area of the study of human environment. The invited contributions offer an excellent survey of and pro­ found insight into specific areas of toxicology and disposition of metals and organic chemicals, and the series of papers on specific subjects bring fresh information on the biotransformation and mechanisms of toxic action of several industrially important solvents tmd monomers of plastics. Rather than from the Preface, the reader should seek guidance from the Index, which clearly shows the overlapping of this area of toxicology with the latest results in biochemistry. We gratefully acknowledge the understanding, care, and preciSion of the publisher that made this book possible. The Editors Contents Metals Metabolic Factors in the Distribution and Half Time of Mercury After Exposure to Different Mercurials 1. Magos. With 1 Figure . . . . . . . . . . . . . . . . . . .. . . . 1 . . . . . Biliary Excretion of Metals M. Cikrt. With 9 Figures. . . . . . . . . . . . . . . . . . . .. . . 17 . . . . .

Inhalt

Metals.- Metabolic Factors in the Distribution and Half Time of Mercury After Exposure to Different Mercurials.- Biliary Excretion of Metals.- Effect of Short Fasts on Heavy Metal Absorption in the Rat.- Failure of Trace Element Additives to Decrease Cadmium, Mercury, and Manganese Absorption in Suckling Rats.- Manganese-Induced Changes in Biotransformation Enzyme Activities in Rats.- Metallothionein in Urine of Cadmium-Exposed Rats: Relation to the Cadmium Deposit and the Injury of Liver and Kidneys.- Biological Monitoring of Exposure to Manganese by Mn Hair Content.- Kinetics of Inhaled Aerosol [8 5 Sr] Cl2.- The Effect of Cadmium on Hepatic Fatty Acid Biosynthesis in Rats.- Inorganic Cations Toxicity-Application of QSAR Analysis.- The Relation Between the Connectivity Index of Some Cations and Their Toxicity.- Human Erythrocyte Membrane Proteins: Interaction with 9 9Molybdenum.- Organic Chemicals.- Potentiation of Haloalkane-Induced Hepatotoxicity and Nephrotoxicity: Role of Biotransformation.- Pulmonary Toxicity of Carbon Tetrachloride.- Rat Liver and Kidney Gluconeogenesis After Acute Intoxication with Carbon Tetrachloride.- Evaluation of Hepatic Mixed Function Oxidase (MFO) Systems After Administration of Allylisopropylacetamide, CCl4 CS2 or Polyriboinosinic Acid. Polyribocytidyclic Acid to Mice.- Molecular Mechanism of the Xenobiotica Metabolizing Enzyme Cytochrome P-450.- Metabolic Activation and Pharmacokinetics in Hazard Assessment of Halogenated Ethylenes.- The Involvement of Bay-Region and Non-Bay-Region Diol-Epoxides in the in Vivo Binding of Benz(a)anthracene Derivatives to DNA.- Replicative Reliability Tests for Environmental Carcinogens.- Cytogenetic Analysis of Peripheral Lymphocytes as a Method for Monitoring Environmental Levels of Mutagens.- Mutagenic Activity of Butadiene, Hexachlorobutadiene, and Isoprene.- Microsomal 4-Vinylcyclohexene Mono-oxygenase and Mutagenic Activitiy of Metabolic Intermediates.- Modeling of Uptake and Clearance of Inhaled Vapors and Gases.- Metabolic Studies on Acrylonitrile.- The Fate of [14C]-Acrylonitrile in Rats.- Conjugation of Glutathione with Acrylonitrile and Glycidonitrile.- Cyanide Effect in Acute Acrylonitrile Poisoning in Mice.- Mutagenic Activity of Oxiranecarbonitrile (Glycidonitrile).- Metabolic and Toxic Interactions of Benzene and Acrylonitrile with Organic Solvents.- Benzene Biotransformation in Rats as Influenced by Substrate Concentration, Product Inhibition and Hepatic Monooxygenase Activity.- Effects of Acute and Chronic Ethanol Consumption on the in Vivo and in Vitro Metabolism of Some Volatile Hydrocarbons.- The Effect of Benzene and Its Methyl Derivatives on the MFO System.- The Effect of Long-term Inhalation of Ortho-Xylene on the Liver.- The Effect of Inhaled C6-C9 Petroleum Fraction on the Biotransformation of Benzene in the Rat.- Induction of Cytochrome P-450 in Rat Liver After Inhalation of Aromatic Organic Solvents.- Alkylation of RNA by Vinyl Chloride and Vinyl Bromide Metabolites in Vivo: Effect on Protein Biosynthesis.- Effects of Ethanol, Diethyl Dithiocarbamate, and (+)-Catechin on Hepatotoxicity and Metabolism of Vinylidene Chloride in Rats.- On the Reaction of Vinyl Chloride and Interaction of Oxygene with DNA.- Induction of MEOS and Binding of Ethanol in the Liver: Microsomes of Female Mice.- Levels of Polychlorinated Biphenyls (PCB's) in Blood as Indices of Exposures.- Effect of Paraquat on Oxidative Enzymes in Vivo.- Early Changes in the Urinary Excretion of Porphyrins by Female Rats in the Course of Chronic TCDD Treatment.- Allylamine Cardiovascular Toxicity: Modulation of the Monoamine Oxidase System and Biotransformation to Acrolein.- Excretion of Dimethyl Phosphate and Its Thioderivatives After Occupational Exposure to Selected Organophosphorus Pesticides.- The Study of Organophosphate Action Using Flow Technicon System.- Effect of Lindane and Lindane Metabolites on Hepatic Xenobiotic Metabolizing Systems.- Regulatory Perspectives on Chemical Compounds Used as Animal Drugs or Feed Additives.- Closing Remarks.