This book sheds new light on "inducible" lymphoid organs (ILOs): antigen presentation sites that are generated de novo in peripheral tissues under various pathogenic conditions. Accomplished immunologists demonstrate that the physiological role of these ILOs is completely different from that of central lymphoid organs, i.e., the lymph nodes or spleen. In addition to the central organs, the ILOs are considered essential structures for the efficient elicitation of adaptive immune responses in lesions.

The respective chapters highlight examples from multiple sites, e.g. the skin, lung, intestinal tract, genital tract, the synovial membrane of the joints and artificial lymph nodes. Accordingly, readers will learn that ILO structure and function can vary substantially, depending on the context.

Presenting the results of the latest immunological research, the book offers a fascinating and insightful read for both scientists and clinicians in the areas of infectious and immune-associated diseases.

Autorentext
Dr. Kenji Kabashima was born in Japan in 1970. He graduated from Kyoto University in 1996 and was trained in Medicine/Dermatology at the United States Naval Hospital in Yokosuka Japan, Kyoto University Hospital, and University of Washington Medical Center. He started research on bioactive lipid mediators at Kyoto University, which led to a PhD. Then he studied at the Department of Dermatology, Kyoto University Graduate School of Medicine, UCSF, and University of Occupational and Environmental Health. Currently, he is a chair/professor at the Department of Dermatology, Kyoto University Graduate School of Medicine, Japan, a principal investigator at the IMB/SIgN, Singapore, and visiting consultant at the National Skin Centre, Singapore. His main interests include the mechanism of inflammatory skin diseases and 3D-visualization of the skin using two-photon microscopy. His hobbies are running and travelling.

Dr. Gyohei Egawa graduated from Saga Medical school (Saga, Japan) in 2001 and was trained in the department of dermatology in Kyoto University (Kyoto, Japan). After getting his PhD, he worked at Kyoto University hospital and Centenary Institute (Sydney, Australia). Currently, he is a senior lecturer at the department of Dermatology in Kyoto University. His main interests are the barrier function of the skin and intravital visualization of the skin immunity.

Klappentext

This book sheds new light on inducible lymphoid organs (ILOs): antigen presentation sites that are generated de novo in peripheral tissues under various pathogenic conditions. Accomplished immunologists demonstrate that the physiological role of these ILOs is completely different from that of central lymphoid organs, i.e., the lymph nodes or spleen. In addition to the central organs, the ILOs are considered essential structures for the efficient elicitation of adaptive immune responses in lesions.

The respective chapters highlight examples from multiple sites, e.g. the skin, lung,  intestinal tract, genital tract, the synovial membrane of the joints and artificial lymph nodes. Accordingly, readers will learn that ILO structure and function can vary substantially, depending on the context.

Presenting the results of the latest immunological research, the book offers a fascinating and insightful read for both scientists and clinicians in the areas of infectious and immune-associated diseases.

Inhalt

Basic structure of the inducible lymphoid organs

[Now recruiting]

Title: Role of iBALT in respiratory immunity

Prof. Troy D. Randall,  [Confirmed]

troyrandall@uabmc.edu  

Division of Clinical Immunology & Rheumatology, UAB  

Title: Inducible M cells in mucosal immunity

Professor David Lo, [Confirmed] 

david.lo@medsch.ucr.edu

University of California, Riverside   

Title: Role of iSALT in skin immunity

Gyohei Egawa and Kenji Kabashima

[Confirmed] 

Title: Memory lymphocyte cluster in genital immunity

Dr. Norifumi Iijima,  [Confirmed] 

niijima@nibiohn.go.jp  

National Institute of Biomedical Innovation, Health and Nutrition (NBIOHN)

Title: Ectopic lymphoid tissue in rheumatoid arthritis

Prof. Costantino Pitzalis,  [Confirmed] 

c.pitzalis@qmul.ac.uk  

William Harvey Research Institute, Barts and the London School of Medicine  

Title:Ectopic lymphoid structure in cancer

[Now recruiting]

Title: Artificial engineering of lymphoid organs

Dr. Takeshi Watanabe,  [Confirmed] 

tthta_w@icloud.com  

Laboratory of Immunology, Institute for Frontier Life and Medical Sciences, Kyoto University