Because the search for safe and effective chemotherapeutic agents has been hindered by antimicrobial resistance and toxic harm, there is a growing need to understand how the immune system can be manipulated to control infections, particularly HIV. In Immunotherapy for Infectious Diseases, Jeffrey M. Jacobson, md, and a group of leading researchers active in the field review the state-of-the-art for treating various infections-particularly HIV-by manipulating the immune system's response rather than by using chemical drugs. The contributors synthesize the principles of immune defense on the molecular level (monoclonal antibodies, vaccines, methods of antigen presentation, and cytokines and cytokine antagonists), as well as on the cellular and clinical levels as a protection against infection. The review of the current state of anti-HIV immunotherapy covers HIV-specific passive and active immunization strategies, gene therapy, and host cell-targeted approaches for treating HIV infection and restoring immune function. Also discussed are immunotherapy for other viral infections, virus-associated malignancies, bacterial infections and sepsis, tuberculosis, and fungal infections.
Comprehensive and cutting-edge, Immunotherapy for Infectious Diseases reviews all the current state-of-the-art developments occurring in this rapidly evolving field and helps set the stage for the early development of better immunologically based therapies for infections.

Klappentext

In Immunotherapy for Infectious Disease, Jeffrey M. Jacobson, MD, and a panel of leading researchers review the state-of-the-art for treating various infections-particularly HIV-by manipulating the immune system's response rather than by chemical drugs. The contributors synthesize the principles of immune defense on the molecular level (monoclonal antibodies, vaccines, methods of antigen presentation, and cytokines and cytokine antagonists), as well as on the cellular and clinical levels levels as a protection against infection. The review of the current state of anti-HIV immunotherapy covers HIV-specific passive and active immunization strategies, gene therapy, and host cell-targeted approaches for treating HIV infection and restoring immune function.

Inhalt

Part I. Basic Principles of Immunity Humoral Immunity Peter L. Nara Some Basic Cellular Immunology Principles Applied to the Pathogenesis of Infectious Diseases R. Pat Bucy and Paul Goepfert Immune Defense at Mucosal Surfaces Prosper N. Boyaka and Jerry R. McGhee Part II. Molecular Basis for Immunotherapy Production of Immunoglobulins and Monoclonal Antibodies Targeting Infectious Diseases Renate Kunert and Hermann Katinger Dendritic Cells: Their Role in the Immune Response to Infectious Organisms and Their Potential Use in Therapeutic Vaccination Smriti K. Kundu-Raychaudhuri and Edgar G. Engleman Cytokines, Cytokine Antagonists, and Growth Factors for Treating Infections Barbara G. Matthews Principles of Vaccine Development Constantin A. Bona Part III. Immunotherapy for HIV Infection Immunopathogenesis of HIV Infection Lawrence M. Fox. Immune Reconstitution with Antiretroviral Chemotherapy Elizabeth Connick Active Immunization as Therapy for HIV Infection Spyros A. Kalams Passive Immunotherapy for HIV Infection Jeffrey M. Jacobson Host Cell-Directed Approaches for Treating HIV and Restoring Immune Function J. Michael Kilby and R. Pat Bucy Gene Therapy for HIV-1 Infection Ralph Dornburg and Roger J. Pomerantz Part IV. Immunotherapy for Infectious Diseases Other than HIV Immunotherapy for Viral Infections Other than HIV Michelle Onorato and Richard B. Pollard Immunotherapy for Virus-Associated Malignancies Uluhan Sili, Helen Heslop, and Cliona M. Rooney Immunotherapy of Bacterial Infections and Sepsis Sam T. Donta Immunotherapy for Tuberculosis and Other Mycobacterial Infections Robert S. Wallis and John L. Johnson Immunotherapy for Fungal Infections ArturoCasadevall Index