This text encompass an up-to-date, comprehensive review of the state-of-the-art for gland preserving therapies. Fully updated and revised, this text evaluates the scientific evidence for the evolving trend to treat intermediate risk, clinically localized prostate cancer in a focally ablative manner with novel gland-preserving, focal therapy methods. Various ablative devices such as high intensity focused ultrasound, irreversible electroporation, photodynamic therapy, cryotherapy and laser ablation, among others, is discussed in regard to their strengths and limitations as a therapeutic modality. Emphasis is placed on patient selection and outcomes utilizing both advanced imaging techniques and pathologic evaluation. Current and new approaches to image cancer foci within the prostate (multiparametric ultrasonography, multiparametric magnetic resonance image, etc) are presented along with various biopsy techniques, including robotics to map prostate cancer. Patient selection based on imaging and genomic classification, adjuvants to enhance therapy, treatment strategy, outcomes and patient centered concerns is discussed, providing an acceptable balance between cancer control and improved quality of life for patients. Written by experts in the field and lavishly illustrated with detailed line-art and photographs, Imaging and Focal Therapy of Early Prostate Cancer, Second Edition is designed as a comprehensive resource for urologists, radiation oncologists, medical oncologists, radiologists, uropathologists, molecular biologists, biomedical engineers, other clinicians -- residents, fellows, nurses and allied professionals -- and researchers with an interest in the diagnosis and novel treatment of prostate cancer. It will provide insight into the latest research and clinical applications of image-guided diagnosis and minimally invasive focal, gland-preserving treatment for prostate cancer.

Autorentext
Thomas J. Polascik, MD, FACS
Division of Urology, Department of Surgery
Duke Cancer Institute
Duke University School of Medicine
Durham, North Carolina, USA

Inhalt

Evolution in the Concept of Focal Therapy: the Story of Breast Cancer and Prostate Cancer.- Targeted Therapy for Localized Kidney Cancer.- Focal Therapy for Prostate Cancer: A Guide for Patients.- Low-Risk Prostate Cancer in North America: Rationale, Uptake, and Limitations of Active Surveillance and Opportunities for Focal Therapy.- Focal Therapy and Active Surveillance in Europe.- Focal Therapy and Active Surveillance of Prostate Cancer in East and Southeast Asia.- Pathologic Rationale for Focal Therapy of Prostate Cancer: Elucidating Tumor Characteristics and Biology.- Identifying and Characterizing the Index Lesion.- Utilizing Biopsy-Based Genomic Assays to Risk-Stratify Patients.- Patient Selection for Focal Therapy of Prostate Cancer.- Prostate Focal Therapy: Definitions and Common Terminology.- Reading and Reporting Standards: The Prostate Imaging Reporting And Data System What Is It and What Can It Do?.- Role of Magnetic Resonance Imaging in Prostate Cancer Assessment.- Optimizing Multiparametric Magnetic Resonance Imaging for a Focal Therapy Practice: Quality Improvement.- Acoustic Radiation Force Impulse Imaging for Targeting: Correlation with Histology.- In-Bore Magnetic Resonance Imaging-Targeted Biopsy.- Multiparametric MRI-TRUS Fusion Biopsy, Outcomes, and Commercial Systems.- Detecting, Localizing, and Treating the Multiparametric Magnetic Resonance Imaging Invisible Lesion: Utilizing Three-Dimensional Transperineal Mapping.- Multiparametric Transrectal Ultrasound Biopsy.- Robotic Magnetic Resonance Imaging Targeting for Biopsy and Therapy.- In-Bore Transperineal Magnetic Resonance Imaging-Guided Laser Ablation.- Focal Cryoablation.- Photodynamic Therapy for Early Prostate Cancer.- High-Intensity Focused Ultrasound.- Transrectal Laser Focal Therapy of Prostate Cancer.- Focal Therapy for Prostate Cancer: a Molecular BiologyApproach with TRAIL.- Focal Therapy for Anterior Cancers (Originated from Transition Zone).- The Story of Adjuvants to Boost the Performance of Cryoablation.- 5-Alpha-Reductase Inhibition as a Secondary Preventive Strategy.- Measuring Patient-Based Outcomes: Setting Realistic Expectations When Balancing Functional Outcomes with Cancer Control.- Pathologic Assessment and Implications Following Focal Therapy of Prostate Cancer.- Post-Treatment Surveillance Using Multiparametric Magnetic Resonance Imaging.- Determining Focal Therapy Failure and Salvage Options.-