This book constitutes the refereed proceedings of the Second International Conference, ICT Innovations 2010, held in Ohrid, Macedonia, in September 2010. The 33 revised papers presented together with 5 invited papers were carefully reviewed and selected. The papers address the following topics: internet applications and services, artificial intelligence, bioinformatics, internet, mobile and wireless technologies, multimedia information systems, computer networks, computer security, e-business, cryptography, high-performance-computing, social networks, e-government, as well as GPU computing.