"Hydrogenosomes and Mitosomes: Mitochondria of Anaerobic Eukaryotes, 2nd edition" provides a comprehensive summary of the current knowledge on these organelles, which occur in unicellular, often parasitic organisms, including human pathogens. It discusses the discovery of these widely distributed organelles, as well as their evolution and recent advances in the study of their structure and function. The book also describes their properties, such as protein import, structure, metabolism and adaptation, their proteome and their role in drug activation and resistance.

The book will appeal to researchers and students interested in biology and medicine, and to those who are mainly interested in basic science-cell biology, parasitology, microbiology, evolution etc., but also to those interested in organelles as potential targets for chemotherapy.

Zusammenfassung

"Hydrogenosomes and Mitosomes: Mitochondria of Anaerobic Eukaryotes" provides a summary of the current knowledge of these organelles, which occur in unicellular, often parasitic organisms, including human pathogens. The distribution of these organelles is broad, but they were detected primarily in an anoxic habitat or nutrient rich intracellular niche that permits life without the efficient energy generating system of typical mitochondria. Their common characteristic is that they lack the aerobic energy conservation system of typical mitochondria and that they are usually the site of the synthesis of iron-sulfur clusters, regarded as the only indispensable function of eukaryotic mitochondria.

These mitochondria-related organelles exhibit a variety of structures and functions. This work describes properties such as protein import, structure, metabolism, adaptation, proteome and their role in drug activation and resistance. Further topics include the evolution and biogenesis of these organelles.

Inhalt

Introduction, history etc.., Miklos Müller, The Rockefeller University, USA,- Anaerobic Eukaryotes in Persuit Normality: the Eolution of mitochondria-derived organelle, William Martin, Germany,- Protein Import into Hydrogenosomes and Mitosomes, Abhijith Radhakrishna Makki, Jan Tachezy, Pavel Doleal,- Structure of the Hydrogenosome (morphogenesis, electron microscopy, comparison of various hydrogenosomes..), Marlene Benchimol, Brasil,- Hydrogenosomes of anaerobic ciliates, Johannes H.P. Hackstein, The Netherlands,- Metabolism of trichomonad hydrogenosomes (energy metabolism, electron transport), Ivan Hrdy, Charles University, Czech Republic,- Hydrogenosomes of anaerobic chytrids (Neocallimastix, Piromyces), L. Tielens, J. Hellemond, F. Voncken, J. Heckstein,- The proteome of T. vaginalis hydrogenosomes, Petr Rada Charles University, Czech Republic,- Mitosomes in parasitic protists: Entamoeba histolytica, Giardia intestinalis, microsporidia, J. Tachezy, Pavel Doleal,- Remnant mitochondria of Cryptosporidium parvum, Anastasios Tsaousis, UK,- Mitochondrion-derived organelles in free-living protists, A. Roger M. Kolísko,- Organisms without mitochondria, how it may happen?, V. Hampl.