In Human Growth Hormone: Research and Clinical Ptractice, Roy Smith and a distinguished panel of researchers and clinicians combine a review of GH regulation and its action at the molecular level with a state-of-the-art description of the basis for GH deficiency and the use of GH therapy in a variety of clinical situations. The clinical uses of GH discussed here move beyond the treatment of GH-deficient children to include the genetics of GH-deficiency, GH-deficiency in adults, osteoporosis, Syndrome X, sleep quality, GH in AIDS patients, and GHRH in clinical studies. Also described are a family of GH-secretagogues that bind to a new orphan receptor controlling the physiology of GH release. The discussion of the new GH therapeutics includes their design, their action as regulators in the pituitary gland and in the central nervous system, and their use as new agents for treating growth hormone deficiency states.

Human Growth Hormone: Research and Clinical Practice offers an unprecedented cutting-edge synthesis of basic science and clinical practice. Timely and innovative, this book will benefit both basic and clinical researchers, as well as those clinical endocrinologists who want to use growth hormone not only in treating children, but also in treating adult disorders, including those associated with metabolic disease.

Klappentext

In a state-of-the-art synthesis of basic science and clinical practice, Roy Smith and a distinguished panel of researchers and clinicians review GH regulation and its action at the molecular level, and describe the basis for GH deficiency and the use of GH as therapy in a variety of clinical situations. The clinical presentation moves beyond the treatment of GH-deficient children to include the genetics of GH-deficiency, GH-deficiency in adults, osteoporosis, Syndrome X, sleep quality, GH in AIDS patients, GHRH in clinical studies. Timely and innovative, Human Growth Hormone: Research and Clinical Practice will benefit both basic and clinical researchers, as well as those clinical endocrinologists who want to use growth hormone not only in treating children, but also in treating adult disorders, including those associated with metabolic disease.

Inhalt

Overview of Human Growth Hormone: Research and Clinical Practice, Roy G. Smith. Part I Research. GHRP Historical Perspective: Basic and Clinical, C. Y. Bowers. The Design of Peptidomimetic Growth Hormone Secretagogues, Arthur A. Patchett and Matthew J. Wyvratt. Molecular Characterization of Growth Hormone Secretagogue Receptors, Andrew D. Howard, Scott D. Feighner, Roy G. Smith, and Lex H. T. Van der Ploeg. Central Actions of Peptide and Nonpeptide Growth Hormone Secretagogues, Suzanne L. Dickson and Gareth Leng. Pharmacology of Growth Hormone-Releasing Hormone and Its Peptide Analogs, David H. Coy. Somostatin Receptor Subtypes and Regulation of GH Secretion, Gurkeerat Singh, George Liapakis, and Terry Reisine. Mathematical Modeling of the GH Release Axis, David Brown, Elinor A. Stephens, Gareth Leng, and Roy G. Smith. Activation of the Human Growth Hormone Receptor: Structure and Function of the Ligand-Receptor Complex, Kenneth H. Pearce, and James A. Wells. The Central Nervous System as a Direct Target for Growth Hormone Action, Pamela A. Bennett and Iain C. A. F. Robinson. Part II Clinical Practice. Molecular Defects of the Growth Hormone Axis, Linda Anne DiMeglio, Paul L. Hofman, and Ora Hirsch Pescovitz. Growth Hormone: Relevance to Pediatrics, Barry B. Bercu and Howard J. Heinze. Growth Hormone Deficiency in Adults: The Rationale for Growth Hormone Replacement, Paul V. Carroll, Emanuel R. Christ, and Peter H. Sönksen. Growth Hormone and Osteoporosis, Howard B. A. Baum and Anne Klibanski. Growth Hormone and Syndrome X, Gudmundur Johannsson, Per Mårin, Jan-Ove Johansson, and Bengt-Åke Bengtsson. Interactions Between Growth Hormone Secretion and Sleep, Eve Van Cauter and Georges Copinschi. Growth Hormone in AIDS, Kathleen Mulligan and Morris Schambelan. Clinical and Physiological Studies With Growth Hormone-Releasing Hormone, George R. Merriam and Fernando Cassorla. Clinical Use of Growth Hormone Secretagogues, Mark A. Bach and Glenn J. Gormley. Index.