Many women have to spend one third of their lives in a postmenopausal state and they should have a good quality of life during this period. Althoug HRT is well accepted as the logical treatment of climacteric problems, the prevalence rate is very low in some countries. The reasons for not accepting HRT are manifold and complex. The objective of this book is to describe the essential advances in basic and clinical research that forms the basis of current HRT and to give an overview of the efficacy and safety of HRT.

Inhalt

General Aspects of Worldwide HRT use; General Aspects of HRT in Japan; Recent Advances in Steroid Receptors Research: Focusin on Estrogen Receptors; Global Effects of Estrogens in the Adult Central Nervous System; HRT and Brain Function: Clinical Aspects; Hormone Replacement Therapy and Lipids; HRT and the Vascular System: Direct Action of Estrogen on Vascular Smooth Muscle Cells; Skin Collagen and HRT; Steroids and Bone-basic Aspects; A Place of Add Back Therapy in Women Treated with GnRH Agonists With Reference to Bone Protection; HRT and Bone-Clinical Aspects; HRT and Climacteric Symptomps: Characteristics in Japanese women