This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields.

By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.

Autorentext

Yujin Hoshida
University of Texas Southwestern Medical Center
Dallas, TX
USA

Inhalt
Part 1: Clinical demographics and management1.Risk Factors of Hepatocellular Carcinoma for Precision Personalized CareNaoto Fujiwara, Po-Hong Liu, Sai Krishna Athuluri-Divakar, Shijia Zhu, Yujin Hoshida2.Hepatocellular Carcinoma Surveillance and StagingAmit G. Singal, Neehar D. Parikh, Nicole E. Rich, Binu V. John, Anjana Pillai3.Changing Epidemiology of Hepatocellular Carcinoma and Role of SurveillanceYueran Zhuo, Qiushi Chen, Jagpreet Chhatwal
Part 2: Diagnosis and prognostication4.Radiological diagnosis and characterization of HCCNaik Vietti Violi, Sara Lewis, Stefanie Hectors, Daniela Said, Bachir Taouli5.Analysis of Hepatocellular Carcinoma Tissue for Biomarker and Therapeutic Target DiscoveryConnor West, Alyson P. Black, Anand S. Mehta6.Molecular subtypes and genomic signatures of hepatocellular carcinoma for prognostication and therapeutic decision makingSung Hwan Lee, Sun Young Yim, Jae-Jun Shim, Ju-Seog Lee7.Liquid Biopsy in Hepatocellular CarcinomaIrun Bhan, Daniel A. Haber, Raymond T. Chung, David T. Ting
Part 3: Treatment8.Surgical Therapies in Hepatocellular CarcinomaCaitlin A. Hester, Adam C. Yopp9.Interventional Radiologic Therapies for Hepatocellular Carcinoma: From Where We Began To Where We Are GoingPatrick D. Sutphin, Daniel Lamus, Sanjeeva P. Kalva, Junjie Li, Ian R. Corbin10.Precision Locoregional Therapies for Hepatocellular Carcinoma: Percutaneous Ablation and RadiotherapyRyosuke Tateishi, Naoto Fujiwara11.Molecular-targeted therapies in hepatocellular carcinomaAmit Mahipal, Anuhya Kommalapati, Rutika Mehta, Richard Kim 12.Immune therapiesZachary J. Brown and Tim F. Greten13.Prevention Strategies for Hepatocellular CarcinomaDerek J. Erstad, Allen A. Razavi, Shen Li, Kenneth K. Tanabe, Bryan C. FuchsPart 4: Molecular pathogenesis and therapeutic discovery14.Molecular Alterations and Heterogeneity in Hepatocellular CarcinomaHsin Hung, Xin Wei Wang15.Stromal and Immune Drivers of HepatocarcinogenesisAntonio Saviano, Natascha Roehlen, Alessia Virzì, Armando Andres Roca Suarez, Yujin Hoshida, Joachim Lupberger, Thomas F. Baumert16.Experimental Models for Preclinical Research in Hepatocellular CarcinomaPedro Molina-Sánchez, Amaia Lujambio