This book gathers a wealth of contributions on the virulence factors and pathogenic mechanism of Helicobacter pylori, prepared by leading international experts. In addition, it explores the epidemiology, diagnosis, treatment with drugs and probiotics, and prophylaxis by vaccination, reflecting the latest advances.

H. pylori is a Gram negative microaerophilic bacterium that can produce various gastric diseases including gastritis, gastroduodenal ulceration, gastric cancer and gastric MALT lymphoma. Although efforts to combat H. pylori using a combination of proton pump inhibitor and several antimicrobial drugs have significantly decreased the burden of these gastric diseases, the microbial epidemiology and gastric pathogenesis following H. pylori infection are still not fully understood.

Given its scope, the book offers a valuable resource not only for basic microbiologists, but also for researchers in the fields of pathology, biochemistry and genomics, as well as medical students/scientists.

Autorentext

Shigeru Kamiya (Kyorin University, Japan)

Steffen Backert (Friedrich-Alexander University Erlangen, Germany**)**

Inhalt
1. Genomic diversity of Helicobacter pylori and human migrationsYoshio Yamaoka(Oita University, Japan) E-mail: yyamaoka@oita-u.ac.jp
2. Epidemiology, diagnosis and risk factors of Helicobacter pylori infectionsEliette Touati (Pasteur Institute, France) E-mail: eliette.touati@pasteur.fr
3. Activities and functional importance of Helicobacter pylori virulence factorsDionyssios Sgouras (Pasteur Institute, France) E-mail: dionsgouras@gmail.com
4. Structural and functional aspects of the Helicobacter pylori proteomeGiuseppe Zanotti (University of Padova, Italy) E-mail: giuseppe.zanotti@unipd.it
5. Role of adhesion to epithelial cells in gastric colonization by H. pyloriEric Sundberg (University of Maryland, USA) E-mail: esundberg@ihv.umaryland.edu
6. Interplay of Helicobacter pylori with immune cells: impact on gastric pathologySteffen Backert  (Friedrich-Alexander University Erlangen, Germany) E-mail: Ebook-Helicobacter@gmx.de
7. Helicobacter pylori infection of childrenMasumi Okuda (Aichi Medical University, Japan) E-mail: okuda@naxnet.or.jp
8. Non-malignant Helicobacter pylori-associated diseasesMichael Vieth (Institute of Pathology, Germany) E-mail: vieth.lkpathol@uni-bayreuth.de
9. Malignant Helicobacter pylori-associated diseases: gastric cancer and MALT lymphomaMasanori Hatakeyama (The University of Tokyo, Japan) E-mail: mhata@m.u-tokyo.ac.jp
10. Host genetic polymorphisms in gastric disease outcomeMargeruite Clyne (University College Dublin, Ireland) E-mail: marguerite.clyne@ucd.ie
11. Helicobacter pylori genetic polymorphisms in gastric disease developmentScott Merrell (Uniformed Services University of the Health Sciences, USA) E-mail: douglas.merrell@usuhs.edu
12. Crosstalk of Helicobacter pylori with the gastrointestinal microbiotaCeu Figueiredo (University of Porto, Portugal) E-mail: cfigueiredo@ipatimup.pt
13. Treatment of Helicobacter pylori infectionAkiko Shiotani  (Kawasaki Medical University, Japan) E-mail: shiotani@med.kawasaki-m.ac.jp
14. Role of probiotics in eradication therapy for Helicobacter pylori infectionShigeru Kamiya (Kyorin University, Japan) E-mail: skamiya@ks.kyorin-u.ac.jp
15. Immunity and vaccine development against Helicobacter pyloriAnna Walduck (RMIT University, Australia) E-mail: anna.walduck@rmit.edu.au