The book Heat Shock Protein 90 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP90. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, previously unknown signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding Oncogenic Aspects of HSP90; Section II, focuses on Bimolecular Aspects of HSP90; Section III, emphasizes and HSP90 in Natural Products Development and Section IV; give the most up to date reviews on Clinical Aspects of HSP90.

Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Natural Products, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Autorentext

Prof. Dr. Alexzander A. A. Asea is a highly innovative and accomplished world renowned clinical and basic research scientist and visionary executive leader who has exceptional experience spearheading clinical and basic science research, training, education, and commercialization initiatives within top ranked academic biomedical institutes. Prof. Dr. Asea's initial findings studying the effects of Hsp72 on human monocytes lead to the proposal of a novel paradigm that Hsp72, previously known to be an intracellular molecular chaperones, can be found in the extracellular milieu where it has regulatory effects on immuno-competent cells - a term now called chaperokine. Prof. Asea has authored over 255 scientific publications including peer-reviewed articles, reviews, books, book chapters, editorials, and news headliners in a wide range of biomedical-related disciplines. Prof. Asea is the series editor of the widely successful book series Heat Shock Proteins (Springer Nature Publishing) and is an editorial board member of numerous scientific peer-reviewed journals. Currently, Prof. Dr. Asea is at the University of Toledo College of Medicine and Life Sciences in Toledo, USA.

Dr. Punit Kaur is an expert in onco-proteogenomics, with extensive training and experience in quantitative mass spectrometry imaging, protein chemistry and biomarker discovery. Dr. Kaur's main research focus is on the use of heat-induced nanotechnology in combination with radiotherapy and chemotherapy in the cancer stem cell therapy. Dr. Kaur has published more than 40 scientific articles, book chapters, and reviews, and currently serves as editorial board member for the European Journal of Cancer Prevention and the Journal of Proteomics and Bioinformatics. Dr. Kaur is an editor of 10 books in the highly successful Heat Shock Proteins book series by Springer Nature Publishers. Currently, Dr. Kaur is a Visiting Scientist Professor at the University of Texas MD Anderson Cancer Center in Houston, USA.

Klappentext

The book Heat Shock Protein 90 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP90. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, previously unknown signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding Oncogenic Aspects of HSP90; Section II, focuses on Bimolecular Aspects of HSP90; Section III, emphasizes and HSP90 in Natural Products Development and Section IV; give the most up to date reviews on Clinical Aspects of HSP90.  

Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Natural Products, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Zusammenfassung

The book **Heat Shock Protein 90 in Human Diseases and Disorders **provides the most comprehensive review on contemporary knowledge on the role of HSP90. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, previously unknown signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding Oncogenic Aspects of HSP90; Section II, focuses on Bimolecular Aspects of HSP90; Section III, emphasizes and HSP90 in Natural Products Development and Section IV; give the most up to date reviews on Clinical Aspects of HSP90.  

Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for starters and professionals in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Natural Products, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Inhalt

SECTION I: ONCOGENIC ASPECTS OF HSP90

Chapter 1. Regulatory Roles Of HSP90-rich Extracellular Vesicles**

Takanori Eguchi, Kisho Ono, Kazumi Kawata, Kuniaki Okamoto and Stuart K Calderwood

Department of Dental Pharmacology and Advanced Research Center for Oral and Craniofacial Sciences

Dentistry and Pharmaceutical Sciences

Okayama University

Okayama, Japan

Chapter 2. HSP90-Based Heterocomplex As Essential Regulator For Cancer Disease

Mario D. Galigniana

Instituto de Biología y Medicina Experimental (IBYME)-CONICET & Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires

Buenos Aires, Argentina******

  Chapter 3. Therapeutic Potential Of Heat Shock Protein 90 Inhibitors In Colorectal Cancer ** Reyhaneh Moradi-Marjaneh, Seyed Mahdi Hassanian, Gordon A. Ferns, Amir Avan and Majid Khazaei Metabolic Syndrome Research Center and Cancer Research Center and Department of Modern Sciences and Technologies, Faculty of Medicine

And

Department of Physiology

Faculty of Medicine

Mashhad University of Medical Sciences

Mashhad, Iran

Chapter 4. Hsp90 In The Migration Of Primordial Germ Cells: A Model To Study Long-Distance Cell Migration And Perhaps Cancer?

Marie Lejong, Nathalie Vanmuylder and Stéphane Louryan

Laboratory of Anatomy

Biomechanics and Organogenesis, Faculty of Medicine

Université Libre de Bruxelles

**Chapter 5. Role Of Heat Shock Protein 90 In Mammary Tumorigenesis **

B.V. Sunil Kumar, Priya K. Gopal and Ramneek Verma

Department of Microbial and Environmental Biotechnology

School of Animal Biotechnology

Guru Angad Dev Veterinary and Animal Sciences University

Ludhiana, India

Chapter 6. Role Of HSP90 Inhibitors In The Treatment Of Cancer

Geraldine O'Sullivan Coyne, Cecilia Monge and Alice P. Chen

Division of Cancer Treatment and Diagnosis and Center for Cancer Research

National Cancer Institute

National Institutes …