The book Heat Shock Protein 60 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP60 in human diseases and disorders. Using an integrative approach, the contributors provide a synopsis of novel mechanisms and signal transduction pathways. To enhance the ease of reading and comprehension the book has further been subdivided into various section including; Section I: Biomolecular Aspects of HSP60; Section II: HSP60 and Cancer; Section III: HSP60 and Inflammatory Diseases and Disorders; Section IV: HSP60 and Cardiovascular Diseases and Disorders; Section V: HSP60 and Neurological and Neurosciences; Section VI: Biomolecular Aspects of HSP60; Section VII: HSP60 and Skeletal Muscle Diseases and Disorders; and Section VIII: HSP60 in Human Health.

Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Neurology & Neuroscience, Oncology, Cardiovascular Disease, Skeletal Muscle Diseases and Disorders, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Autorentext

Prof. Dr. Alexzander A. A. Asea is a highly innovative and accomplished world renowned clinical and basic research scientist and visionary executive leader who has exceptional experience spearheading clinical and basic science research, training, education, and commercialization initiatives within top ranked academic biomedical institutes. Prof. Dr. Asea's initial findings studying the effects of Hsp72 on human monocytes lead to the proposal of a novel paradigm that Hsp72, previously known to be an intracellular molecular chaperones, can be found in the extracellular milieu where it has regulatory effects on immuno-competent cells - a term now called chaperokine. Prof. Asea has authored over 255 scientific publications including peer-reviewed articles, reviews, books, book chapters, editorials, and news headliners in a wide range of biomedical-related disciplines. Prof. Asea is the series editor of the widely successful book series Heat Shock Proteins (Springer Nature Publishing) and is an editorial board member of numerous scientific peer-reviewed journals. Currently, Prof. Dr. Asea is at the University of Toledo College of Medicine and Life Sciences in Toledo, USA.

Dr. Punit Kaur is an expert in onco-proteogenomics, with extensive training and experience in quantitative mass spectrometry imaging, protein chemistry and biomarker discovery. Dr. Kaur's main research focus is on the use of heat-induced nanotechnology in combination with radiotherapy and chemotherapy in the cancer stem cell therapy. Dr. Kaur has published more than 40 scientific articles, book chapters, and reviews, and currently serves as editorial board member for the European Journal of Cancer Prevention and the Journal of Proteomics and Bioinformatics. Dr. Kaur is an editor of 9 books in the highly successful Heat Shock Proteins book series by Springer Nature Publishers. Currently, Dr. Kaur is a Visiting Scientist Professor at the University of Texas MD Anderson Cancer Center in Houston, USA.

Klappentext

The book Heat Shock Protein 60 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP60 in human diseases and disorders. Using an integrative approach, the contributors provide a synopsis of novel mechanisms and signal transduction pathways. To enhance the ease of reading and comprehension the book has further been subdivided into various section including; Section I: Biomolecular Aspects of HSP60; Section II: HSP60 and Cancer; Section III: HSP60 and Inflammatory Diseases and Disorders; Section IV: HSP60 and Cardiovascular Diseases and Disorders; Section V: HSP60 and Neurological and Neurosciences; Section VI: Biomolecular Aspects of HSP60; Section VII: HSP60 and Skeletal Muscle Diseases and Disorders; and Section VIII: HSP60 in Human Health.

Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Neurology & Neuroscience, Oncology, Cardiovascular Disease, Skeletal Muscle Diseases and Disorders, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Inhalt

SECTION I: BIOMOLECULAR ASPECTS OF HSP60

Chapter 1. HSP60: A Story as Long as Life on the Earth

Francesco Cappello, Everly Conway de Macario and Alberto JL Macari

Department of Experimental Medicine and Clinical Neurosciences

University of Palermo

Palermo, Italy

**Chapter 2.* ***Single-Ring Intermediates in the Catalytic Cycle of the Human Mitochondrial HSP60

Jay M. Bhatt and Ricardo A. Bernal

Department of Chemistry and Biochemistry

The University of Texas at El Paso

El Paso, Texas 

**Chapter 3. ****HSP60 Inhibitors and Modulators

Antonio Palumbo Piccionello, Paola Marzullo, Silvestre Buscemi and Andrea Pace

Dipartimento di Scienze e Tecnologie Biologiche (STEBICEF)

University of Palermo

Palermo, Italy

**Chapter 4. ****HSP60 as Modulators of Apoptosis

Naira Rashid and Pratima Chaudhuri (Chattopadhyay)

Molecular Biophysics Lab

Amity University Noida, Uttar Pradesh, India

**Chapter 5. ****Utilizing The Unique Architecture And Abilities of Hsp60 In Drug Development

Tomohiro Mizobata and Yasushi Kawata

Department of Faculty of Engineering and Center for Research on Green Sustainable Chemistry

Tottori University Tottori, Japan

Chapter 6. Role of The Post-Translational Modifications of HSP60 In Disease Byron Baron

Department of Medicine and Surgery

University of Malta

Msida, Malta******

SECTION II: HSP60 AND CANCER

Chapter 7. Evaluation of Heat Shock Protein 60 (HSP60) Chaperonin in Oncology

smail Aababaolu

Chapter 8. **Exosomal Hsp60: a Tumor Biomarker?

Stefano Fais, Mariantonia Logozzi, Giusi Alberti and Claudia Campanella

Department of Experimental Biomedicine and Clinical Neurosciences

University of Palermo

Palermo, Italy

Chapter 9. ****HSP60 in Cancer Immunity: Biological Basis, Diagnostic Potential and Therapeutic Opportunities **

Christian R. Gomez

Department of Pathology and Radiation Oncology

University of Mississippi Medical Center

Jackson, MS

Chapter 10. **Hsp60 Involvement During Carcinogenesis

Francesca Rappa, Francesco Carini and Pierre Schembri Wismayer

Department of Experimental Biomedicine and Clinical Neurosciences

University of Palermo

Palermo, Italy

  SECTION III: HSP60 AND INFLAMMATORY DISEASES AND DISORDERS

**Chapter 11. ****Anti-Human Hsp60 Autoantibodies in Autoimmune and Inflammatory Rheumatic Diseases

Georgios Efthymiou, Lazarosi Sakkas and Dimitrios P. Bogdanos

Department of Rheumatology and Clinical Immunology

University General Hospital of Larissa School of Health Sciences

University of Thessaly

Viopolis, Greece

  Chapter 12. *****Hs...