This textbook introduces readers to the scientific basics of cardiovascular medicine and biology. It covers not only developmental but also cellular and molecular aspects of normally functioning vasculature and the heart; importantly, it also addresses the mechanisms leading to and involved in specific cardiovascular diseases. Though the main emphasis is on novel therapies and potential therapeutic targets, specific controversial topics like cardiac remodeling and regenerative capacities are also addressed.

All chapters were written by lecturers from the Imperial College London, in collaboration with their students from the College's BSc Programme in Medical Sciences with Cardiovascular Science. Bridging the gap between clinics and basic biology, the book offers a valuable guide for medical students, and for Master and PhD students in Cardiovascular Biomedicine.

Autorentext

Cesare Terracciano is a Professor of Cardiac Electrophysiology, Director of the BSc course in Cardiovascular Sciences at Imperial College London, and a PI of the British Heart Foundation Cardiovascular Regenerative Centre, UK.

Samuel Guymer is a medical student at St. George's, University of London and graduate of the Cardiovascular Sciences, BSc programme at Imperial College London.

Inhalt

• Cardiac Development and Congenital Heart Disease:Cardiac Development Biology - Early Mechanisms

Cardiac Development Biology - Late Mechanisms

Cardiomyocyte Structure and Function

Cardiac Morphology - Anatomy of Congenital Heart Disease

Common Congenital Abnormalities

• The Science of Arrhythmia:

Introduction to the Action Potential

Ion transporters and their Properties

Excitation Contraction Coupling

Tachyarrhythmias

Bradyarrhythmias

• The Science of Heart Failure:

Cardiac Contractility - Normal and Pathological

Heart Failure - A Scientific Perspective Cardiomyopathy

Therapeutics

Novel Therapies

• The Science of Vascular Disease:

The Vasculature - Pharmacological Targets

The Coagulation Cascade and its Therapeutic Modulation

Cellular and Molecular Mechanisms of Atherosclerosis

Cellular and Molecular Mechanisms of Angiogenesis

Endothelial Function and Dysfunction