Springer Advanced Texts in Chemistry New textbooks at all levels of chemistry appear with great regularity. Some fields like basic biochemistry, organic reaction mechanisms, and chemical ther­ modynamics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially many of those taught at the graduate level, suffer from a real lack of up-to-date textbooks. The most serious needs occur in fields that are rapidly changing. Textbooks in these subjects usually have to be written by scientists actually involved in the research which is advancing the field. It is not often easy to persuade such individuals to set time aside to help spread the knowledge they have accumulated. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive introductions to their fields. These should serve the needs of one semester or one quarter graduate courses in chemistry and biochemistry. In some cases the availability of texts in active research areas should help stimulate the creation of new courses. New York, New York CHARLES R.

Inhalt

1 Introduction to Bioorganic Chemistry.- 1.1 Basic Considerations.- 1.2 Proximity Effects in Organic Chemistry.- 1.3 Molecular Adaptation.- 2 Bioorganic Chemistry of the Amino Acids.- 2.1 General Properties.- 2.2 Dissociation Behavior.- 2.3 Alkylations.- 2.4 Acylations.- 2.5 Biological Synthesis of Proteins.- 2.6 Chemical Synthesis of Proteins.- 2.7 Asymmetric Synthesis of a-Amino Acids.- 3 Bioorganic Chemistry of the Phosphates.- 3.1 Biological Role of Phosphate Macromolecules.- 3.2 General Properties.- 3.3 Hydrolytic Pathways.- 3.4 Other Nucleotide Phosphates.- 3.5 Biological Synthesis of Polynucleotides.- 3.6 Chemical Synthesis of Polynucleotides.- 3.7 Chemical Evolution of Biopolymers.- 4 Enzyme Chemistry.- 4.1 Introduction to Catalysis.- 4.2 Introduction to Enzymes.- 4.3 Multifunctional Catalysis and Simple Models.- 4.4 ?-Chymotrypsin.- 4.5 Other Hydrolytic Enzymes.- 4.6 Stereoelectronic Control in Hydrolytic Reactions.- 4.7 Immobilized Enzymes and Enzyme Technology.- 5 Enzyme Models.- 5.1 Host - Guest Complexation Chemistry.- 5.2 Micelles.- 5.3 Polymers.- 5.4 Cyclodextrins.- 5.5 Enzyme Design Using Steroid Template.- 5.6 Remote Functionalization Reactions.- 5.7 Biomimetic Polyene Cyclizations.- 6 Metal Ions.- 6.1 Metal Ions in Proteins and Biological Molecules.- 6.2 Carboxypeptidase A and the Role of Zinc.- 6.3 Hydrolysis of Amino Acid Esters and Amides and Peptides.- 6.4 Iron and Oxygen Transport.- 6.5 Copper Ion.- 6.6 Cobalt and Vitamin B12 Action.- 7 Coenzyme Chemistry.- 7.1 Oxidoreduction.- 7.2 Pyridoxal Phosphate.- 7.3 Thiamine.- 7.4 Biotin.- References.