The aim of this symposium was to provide basic and clinical investigators with the latest information on the biology of wound healing and tissue repair. Written and edited by eminent experts in the field, the papers cover the general concepts of wound healing; the role of nutrients; endogenous growth factors; clinical applications of growth hormone and IGF-1 therapy; and clinical applications of peptide growth factors.

Inhalt

I. General Concepts.- 1. An Overview of Wound Healing Biology.- 2. Growth Factors and Angiogenesis in Wound Healing.- 3. The Regulation of Basic Fibroblast Growth Factor (FGF-2) Through Limited Bioavailability.- 4. Cultured Skin Cells for Wound Closure and for Promoting Wound Healing.- 5. The Growth Hormone Insulin-Like Growth Factor-I Axis.- II. Role of Nutrients in Wound Healing Responses.- 6. Use of Exogenous Amino Acids in Wound Healing.- 7. Vitamin A-Growth Factor Interactions in Wound Healing.- 8. Interactions Between Nutrients and Growth Factors in Cellular Anabolism and Tissue Repair.- III. Endogenous Growth Factors and Wound Healing.- 9. Fibroblast Growth Factor Receptors.- 10. Arginine and Nitric Oxide (NO) Interactions in the Healing Wound.- 11. Endogenous Growth Factors and Nutrients in the Healing Wound.- 12. Epidermal Growth Factor in Wound Healing: A Model for the Molecular Pathogenesis of Chronic Wounds.- IV. Clinical Application of Growth Hormone and IGF-I Therapy.- 13. Growth Hormone Therapy in Human Burn Injury.- 14. Effects of Exogenous Growth Hormone in Postoperative Immune Function and Other Clinical Outcomes.- 15. Effect of Growth Hormone Administration on Colonic Healing and Repair.- 16. Modulation of IGF-I Therapy by IGFBP-3: Potential Utility in Wound Healing.- V. Clinical Application of Peptide Growth Factors.- 17. Roles of Keratinocyte Growth Factor in Epithelial Growth and Regeneration.- 18. Hepatocyte Growth Factor.- 19. The Biology of Vascular Endothelial Growth Factor, a Specific Regulator of Angiogenesis.- 20. FDA Regulatory Concerns for Wound Healing Biologics.- Author Index.