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Glioma Signaling

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Glioma Signaling is a text reference on cellular signaling processes focused on the mechanism of nucleotide receptors activation b... Weiterlesen
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Beschreibung

Glioma Signaling is a text reference on cellular signaling processes focused on the mechanism of nucleotide receptors activation by exogenic nucleotides and the formation of complex signaling cascades, including cytoplasmic transcription factors, induced by growth factors, cytokines and cannabinoids. The book provides a framework explaining how signal transduction elements may modulate glioma cytoskeleton structure, cytoplasmic calcium concentration changes, cellular growth, progression and invasion, as well as presents perspective concerning potential targets for glioma therapy.

Klappentext

Gliomas, developing in the brain from the transformed glial cells, are a very special kind of tumors, extremely refractory to conventional treatments. Therefore, for the development of new antitumor strategies, a better understanding of molecular mechanisms responsible for their biology, growth and invasion is still needed. Glioma Signaling is a text reference on cellular signaling processes regulating gliomas physiology and invasiveness. The first half of the book is focused on the mechanism of nucleotide receptor activation by exogenous nucleotides. The remaining chapters deal with the formation of complex signaling cascades, including cytoplasmic transcription factors, induced by growth factors, cytokines and cannabinoids. The book provides a framework explaining how signal transduction elements may modulate glioma cytoskeleton structure, cytoplasmic calcium concentration, cellular growth, progression and invasion, as well as presents perspectives concerning potential targets for glioma therapy.



Inhalt

1. INTRODUCTION TO PURINERGIC SIGNALING IN THE BRAIN

Geoffrey Burnstock

Abstract

1.1 Introduction

1.2 Purinergic Signalling in the CNS

1.2.1 Cotransmission

1.2.2 Glial Cells

1.2.3 Neuron-Glial Interactions

1.3 Purinergic Signalling in Normal Behaviour

1.4 Purinergic Pathophysiology in the CNS, including Gliomas

References

2. ADENOSINE SIGNALING IN GLIOMA CELLS

Stefania Ceruti and Maria P. Abbracchio

Abstract

2.1 Introduction

2.2 Adenosine Metabolism and P1 Adenosine Receptors

2.3 A Role for Ecto-5'-Nucleotidases CD39 and CD73 in Gliomas?

2.4 Receptor-Mediated Effects of Adenosine on Glioma Cell Growth and Survival

2.4.1 A1-, A2A-, and A2B-Mediated Effects on Glioma Cells

2.4.2 The A3 Receptor Subtype as a New Pharmacological Ttarget for Innovative Chemotherapic Approaches to Gliomas

2.5 Receptor-Idependent Effects of Adenosine Analogues on Glioma Cell Growth and Survival

2.6 Conclusions and Future Perspectives

References

3. CROSS-TALK IN NUCLEOTIDE SIGNALING IN GLIOMA C6 CELLS

Dorota Wypych and Jolanta Baraska

Abstract

3.1 Introduction

3.2 Properties of P2 Receptors

3.2.1 P2X Receptors

3.2.2 P2Y Receptors

3.3 P2Y1, P2Y2 and P2Y12 Rreceptor Expression and Functionality in Rat Glioma C6 cells

3.4 Serum Withdrawal

3.4.1 Effect on P2Y1 and P2Y12 Receptor Expression

3.4.2 Effect on C6 cell Morphology, Growth and Differentiation

3.4.3 Effect on the P2Y14 Receptor

3.5 Cyclic AMP Effect on Cell Proliferation, Growth and Differentiation

3.6 Effect of Extracellular Nucleotides on ERK1/2 and PI3K/Akt Activity: P2Y1 and P2Y12 Cross-Talk.

3.7 The P2X7 Receptor

3.8 Concluding Remarks

References

4. CALCIUM SIGNALING IN GLIOMA CELLS THE ROLE OF NUCLEOTIDE RECEPTORS

Dorota Wypych and Pawel Pomorski

Abstract

4.1 Origin of the Calcium Signaling

4.2 Sources of the Calcium Signal

4.2.1 Extracellular Calcium Signal

4.2.2 Signal Generated by Calcium Stores

4.2.2.1 Store Operated Calcium Signaling

4.2.2.2 Calcium-Induced Calcium Signaling

4.3 Calcium Signaling in Non-Excitable Glial Cells

4.3.1 Astrocytes

4.3.2 Microglia

4.4 Nucleotide Receptors-Evoked Calcium Signaling in Glial Cells

4.5 Glioma C6: a Case Study

4.5.1 The Nature of the Signal the Role of Nucleotide Receptors in Glioma C6 Cells

4.6 Gliomas: The Motile Tumors, Calcium Signaling and Chemotaxis

4.6.1 The Calcium Signal in Glioma C6 is Strongly Dependent on Actin Cytoskeleton

4.7 Concluding Remarks

References

5. PURINERGIC SIGNALING IN GLIOMA PROGRESSION

Elizandra Braganhol, Márcia Rosângela Wink, Guido Lenz and Ana Maria Oliveira Battastini

Abstract

5.1 Introduction

5.1.1 Molecular and Cellular Origins of Gliomas

5.1.2 Glioma Cancer Stem Cells (CSCs)

5.1.3 Tumor Microenvironment Key for Understanding and Targeting Gliomas

5.2 Purinergic Signaling in Gliomas

5.3 Ectonucleotidases

5.3.1 Ectonucleoside Triphosphate Diphosphohydrolases (E-NTPDases)

5.3.2 Ectonucleotide Pyrophosphatase/Phosphodiesterases (E-NPPs)

5.3.3 Ecto-Alkaline Phosphatases (ALP)

5.3.4 Ecto-5'-Nucleotidase (ecto-5'-NT/CD73)

5.4 Ecto-adenosine Deaminase (ecto...

Produktinformationen

Titel: Glioma Signaling
Editor:
EAN: 9789400747197
ISBN: 978-94-007-4719-7
Digitaler Kopierschutz: Wasserzeichen
Format: E-Book (pdf)
Herausgeber: Springer
Genre: Medizin
Anzahl Seiten: 227
Veröffentlichung: 10.08.2012
Jahr: 2012
Untertitel: Englisch
Dateigrösse: 5.8 MB

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