Contained in this volume are the proceedings of the international conference on the "Genetic Toxicology of Complex Mixtures," held from July 4-7, 1989, in Washington, DC. This meeting was a satellite of the "Fifth International Conference on Environmental Mutagens" and the seventh in a biennial series of conferences on "Short-term Bioassays in the Analysis of Complex Environmental Mixtures. " Our central objective in calling together key researchers from around the world was to extend our knowledge of the application of the methods of genetic toxicology and analytical chemistry in the evaluation of chemical mixtures as they exist in the environment. This conference emphasized the study of genotoxicants in air and water, and the assessment of human exposure and cancer risk. The latest strategies and methodologies for biomonitoring of genotoxicants (including transformation products) were described in the context of the ambient environment. Source character­ ization and source apportionment were discussed as an aid to understand­ ing the origin and relative contribution of various kinds of complex mix­ tures to the ambient environment. Similarly, investigations of genotoxi­ cants found in the indoor environment (sidestream cigarette smoke) and in drinking water (chlorohydroxyfuranones) were given special attention in terms of their potential health impacts. New molecular techniques were described to enable more precise quantitation of internal dose and dose­ to-target tissues. The emphasis of presentations on exposures/effects assessment was on integrated quantitative evaluation of human exposure and potential health effects.

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Development and Application of New Methodologies Applicable to Research on Complex Environmental Mixtures.- Complex Mixtures of Genotoxicants in Air.- Identification of Genotoxic Agents in Complex Mixtures of Air Pollutants.- Human Exposure to Airborne Mutagens Indoors and Outdoors Using Mutagenesis and Chemical Analysis Methods.- Genetic Toxicology of Airborne Particulate Matter Using Cytogenetic Assays and Microbial Mutagenicity Assays.- Indoor and Outdoor Sources of Airborne Mutagens in Nonurban Areas.- Characterization of Mutagen Sources in Urban Particulate Matter in Gothenburg, Sweden.- Assessment of the Mutagenicity of Volatile Organic Air Pollutants Before and After Atmospheric Transformation.- Carcinogenicity of Complex Mixtures in Air Using In Vitro and In Vivo Assays.- Contribution of Polycyclic Aromatic Hydrocarbons and Other Polycyclic Aromatic Compounds to the Carcinogenicity of Combustion Sources and Air Pollution.- Old and New Carcinogens.- Experimental and Epidemiologic Applications to Cancer Risk Assessment of Complex Mixtures.- Mutagenicity, Carcinogenicity, and Human Cancer Risk from Indoor Exposure to Coal and Wood Combustion in Xuan Wei, China.- The Role of Nitroarenes in the Mutagenicity of Airborne Particles Indoors and Outdoors.- Complex Mixtures of Genotoxicants in Waters.- Characterization of Mutagenic Compounds Formed During Disinfection of Drinking Water.- Genotoxic and Carcinogenic Properties of Chlorinated Furanones: Important By-products of Water Chlorination.- Assessment and Identification of Genotoxic Compounds in Water.- Methods to Measure Genotoxins in Wastewater: Evaluation with In Vivo and In Vitro Tests.- Detection of Genotoxicity in Chlorinated or Ozonated Drinking Water Using an Amphibian Micronucleus Test.- Exposure/Effects Assessment.- The Significance of Mutagenicity as a Criterion in Ecotoxicological Evaluations.- DNA Adducts and Related Biomarkers in Assessing the Risk of Complex Mixtures.- Immunological Methods for the Detection of Polycyclic Aromatic Hydrocarbon-DNA and Protein Adducts.- 32P-Postlabeling DNA Adduct Assay: Cigarette Smoke-induced DNA Adducts in the Respiratory and Nonrespiratory Rat Tissues.- Postlabeling Analysis of Polycyclic Aromatic Hydrocarbon: DNA Adducts in White Blood Cells of Foundry Workers.- Protein Adducts as Biomarkers for Chemical Carcinogens.- Evaluation of DNA Binding In Vivo for Low-Dose Extrapolation in Chemical Carcinogenesis.- Cancer Risks Due to Occupational Exposure to Polycyclic Aromatic Hydrocarbons: A Preliminary Report.- Future Directions in Research on the Genetic Toxicology of Complex Mixtures.