This book brings together the world's leading authorities on tumor immunology. This book describes the basic immunology principles that form the foundation of understanding how the immune system recognizes and rejects tumor cells. The role of the innate and adaptive immune responses is discussed and the implications of these responses for the design of clinical strategies to combat cancer are illustrated.

Zusammenfassung

"General Principles of Tumor Immunotherapy: Basic and Clinical Applications of Tumor Immunology" brings together the world's leading authorities on tumor immunology. This book describes the basic immunology principles that form the foundation of understanding how the immune system recognizes and rejects tumor cells. The role of the innate and adaptive immune responses is discussed and the implications of these responses for the design of clinical strategies to combat cancer are illustrated through both experimental clinical trials and review of current standard of care therapeutic agents. This information will be invaluable to both students of immunology and cancer research and practicing physicians who have patients with cancer. The book provides a comprehensive overview of the field, demonstrates how advances in basic immunology can and are being applied to cancer, and describes the current status of approved immunotherapy regimens.

Inhalt
General Principles of Tumor Immunology.- A Perspective on Cancer Immunology and Immunotherapy.- Tumor Antigens.- T Cells and Antigen Recognition.- The Role of Natural Killer T cells in Tumor Immunity.- Immunomodulatory Molecules of the Immune System.- HLA Class I Antigen Abnormalities in Tumors.- The Local Tumor Microenvironment.- Tumor Vaccines.- Peptide and Protein Vaccines for Cancer.- DNA Vaccines Against Cancer.- Recombinant Viral and Bacterial Vaccines.- Dendritic Cell Vaccines.- Whole Cell Vaccines.- Carbohydrate Vaccines Against Cancer.- Passive Immunotherapy Approaches.- Monoclonal Antibody Therapy of Cancer.- Adoptive Cellular Therapy for the Treatment of Cancer.- Checkpoint Blockade and Combinatorial Immunotherapies.- Clinical Tumor Immunotherapy.- General Approaches to Measuring Immune Responses.- Interferon Therapy.- High Dose Interleukin-2 Therapy.- Monoclonal Antibodies in Cancer Therapy.- Unmasking tumor cell immunogenicity by chemotherapy: implications for therapy.