This book is the proceedings of two symposia, on Proteins of the Nervous System and Myelin Proteins, held as part of the Third Meeting of the International Society of Neurochemistry in Budapest, July 1971. If confirmation of the utility for such a book was needed, it was obtained with the independent publication of a review on Proteins of the Nervous System (1) covering essentially the same ground. This review is an excellent collection of the earlier litera­ ture. The present volume summarizes the more recent advances in this field, and in addition covers those areas, glycoproteins and peptide hydrolases, which were not dealt with by Shooter and Einstein (1). We are most grateful to Miss V. Troeger for typing the man- scripts and to Mr. A. Landmann for assistance with photography. A.N. DAVISON I.G. MORGAN P. MANDEL (1) SHOOTER, E.M. and EINSTEIN, E.R., Ann. Rev. Biochem., 40 (1971) 635.

Inhalt

Section 1 Neurospecific Proteins of Unknown Function.- Introductory Remarks.- Chemistry and Biology of two Brain-Specific Proteins, S-100and 14-3-2.- The Heterogeneity of the S-100 Protein Fraction.- Immunological Studies of Brain Specific Protein.- Brain Glycoprotein 10BFurther Evidence of the "Sign-Post" Role of Brain Glycoproteins in Cell Recognition, its Change in Brain Tumor, and the Presence of a "Distance Factor".- Section 2 Proteins of Functional Importance in the Nervous System.- Some Biochemical Aspects of Neurotubule and Neurofilament Proteins.- Membrane Proteins of Catecholamine-Storing Vesicles in Adrenal Medulla and Sympathetic Nerves.- Biological Properties of the Nerve Growth Factor.- The Physical and Biological Properties of 7S and 3-NGF from the Mouse Submaxillary Gland.- Structural Studies of 2.5 S Mouse Submaxillary Gland Nerve Growth Factor.- Section 3 Cerebral Glycoproteins.- Biochemistry, Function, and Neuropathology of the Glycoproteins in Brain Tissue.- Glycoproteins of the Synaptic Region.- Section 4 Myelin Proteins.- Separation and Characterization of Myelin Proteins.- Proteolipids.- Myelin Basic Proteins.- The Chemical and Immunologic Properties of the Basic Al Protein of Myelin.- The Control of Myelin Synthesis and Inborn Errors of Metabolism.- Isolation and Characterization of Myelin Protein from Adult Quaking Mice and its Similarity to Myelin Protein of Young Normal Mice.- Myelin Enzymes and Protein Metabolism.- Concluding Remarks.