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Inhalt

I. Phenothiazine Derivatives.- A. Structure-activity Relationships.- B. Peripheral Effects.- 1. Adrenolytic, Cholinolytic, Antihistaminic and Anti-serotonin Effects.- 2. Effects on Heart, Circulation and Vasculature.- 3. Muscle Relaxant Effect.- 4. Miscellaneous Effects.- C. Central Effects.- 1. Effects on the Spinal Cord.- 2. Influence on Medullary, Mesencephalic and Diencephalic Autonomic Functions.- a) Antiemetic Effect.- b) Influence on Central Mechanisms Governing Circulation.- c) Effects on Body Temperature.- d) Effect on Appetite.- e) Influence on Central Sympathetic Mechanisms.- 3. Influence on Bioelectrical Phenomena in the CNS.- a) Changes in the EEG.- b) Effect on EEG Arousal Reaction.- c) Influence on the Electrical Activity of the Reticular Formation.- d) Influence on Thalamic Projection System.- e) Effect on the Limbic System.- f) Effects on the Cortex.- g) Interpretation of Electrophysiological Effects.- 4. Results from Behavioral Investigations.- a) Influence on General Behavior.- b) Effect on Operant Conditioned Behavior.- 5. Biochemical Effects on the CNS.- a) Influence on Respiration, Oxidative Phosphorylation, Phospholipid Metabolism and Various Enzymes.- b) Acetylcholine Metabolism.- c) Norepinephrine, Dopamine and 5-HT Metabolism.- 6. Extrapyramidal Motor Disturbances in Man and Catalepsy in Animals.- a) Extrapyramidal Motor Disturbances in Man.- b) Catalepsy in Animals.- c) Biochemical Considerations of Phenothiazine Effects on the Extrapyramidal System.- 7. Interaction of Phenothiazines with other Centrally Acting Agents.- a) General Anesthetics and Hypnotics.- b) Central Stimulants, Convulsants, Physostigmine.- c) Influence on Central Effects of Morphine.- D. Endocrine Effects.- E. Metabolic Fate of Phenothiazines.- F. Habituation and Withdrawal.- G. Adverse Reactions and Treatment Risks.- 1. Suicide and Fatal Poisoning.- 2. Central Nervous System.- 3. Autonomic Nervous System.- 4. Striated Musculature.- 5. Jaundice.- 6. Agranulocytosis.- 7. Allergic Skin Reactions.- 8. Ocular Side-effects.- 9. Teratogenicity.- 10. Danger of Suicide.- 11. Sudden Death.- II. Butyrophenones.- A. Structure Activity Relationships.- B. Peripheral Effects.- 1. Interference with Autonomic Mediators.- 2. Cardiovascular Effects.- C. Central Effects.- 1. Influence at the Spinal Level.- 2. Supraspinal Effects.- a) Antiemetic Effect.- b) Interactions with Centrally Active Agents.- 3. Effects on Behavior.- a) Effects on Innate Behavior.- b) Effects on Operant Behavior.- D. Biochemical Effects.- 1. Interaction with Adrenergic Mediators.- 2. Metabolic Fate.- E. Adverse Reactions and Dangers.- III. Reserpine and Reserpine-like Agents.- A. Structure-activity Relationships.- B. Peripheral Effects.- 1. Influence on the Peripheral Sympathetic Nervous System.- 2. Catecholamine Release from Adrenal Medulla.- 3. Reserpine-induced Release of 5-Hydroxytryptamine.- 4. Mechanism of the Amine-liberating Effect of Reserpine.- 5. Peripheral Consequences of the Biochemical Effects of Reserpine.- C. Central Effects.- 1. Biochemical Effects in CNS.- a) Influence on Norepinephrine, Dopamine and 5-HT Metabolism in Brain.- b) Mechanism of Amine Release by Reserpine in CNS.- c) Relationship between Amine Depletion and Central Reserpine Effects.- d) Other Biochemical Effects of Reserpine in CNS.- 2. Effects on the Spinal Cord.- 3. Influence of Reserpine on Medullar, Meso- and Diencephalic Autonomic Functions.- a) Antiemetic Effect.- b) Influence on Central Regulation of Circulation.- c) Influence on Body Temperature and Appetite.- d) Influence on Central Sympathetic Mechanisms.- 4. Influence on Electrophysiologic Manifestations in Brain.- a) EEG Changes.- b) Influence on Thalamic Projection Systems.- c) Influence on the Limbic System.- d) Effects on Cortex.- 5. Influence of Reserpine on Behavior.- 6. Extrapyramidal Motor Disturbances in Man and Catalepsy in Animals.- 7. Interactions of Reserpine with other Centrally Active Agents.- D. Endocrine Effects of Reserpine.- E. Metabolic Fate of Reserpine.- F. Adverse Reactions and Dangers.- 1. Suicide and Fatal Poisoning.- 2. Central Nervous System.- 3. Autonomic Nervous System.- 4. Miscellaneous Side-effects.- IV. Minor Tranquilizers.- A. Central Effects.- B. Peripheral Effects.- C. Metabolic Studies.- D. Adverse Reactions.- V. Monoamine Oxidase Inhibitors.- A. The Physiologic Significance of Monoamine Oxidase.- B. Classification of MAO-inhibitors and their Structure-activity Relationship.- 1. Hydrazine Derivatives.- 2. Harmala-alkaloids.- 3. Indolylalkylamines.- 4. Propargylamines.- 5. Cyclopropylamine.- 6. Aminopyrazine.- 7. Structural Similarities to Endogenous Amines.- C. Biochemical and Pharmacologic Effects of MAO-inhibitors.- 1. Biochemical Effects of MAO-inhibition.- a) Effects on Monoamine Metabolism.- b) Metabolism of Exogenous Monoamines and their Precursors after Administration of MAO-inhibitors.- c) The Excretion of Endogenous and Exogenous Monoamines and their Metabolites after Administration of MAO-inhibitors.- d) Antagonism between MAO-inhibitors of Short and Long Duration.- e) Antagonism between MAO-inhibitors and Reserpine.- f) Mechanism of the Biochemical Effects of MAO-inhibitors.- 2. Pharmacological Effects of MAO-inhibitors.- a) Central Effects.- b) Peripheral Effects.- D. Fate of MAO-inhibitors in the Body.- E. Adverse Reactions and Dangers.- 1. Suicide and Fatal Poisoning.- 2. Central Nervous System.- 3. Autonomic Nervous System.- 4. Jaundice.- 5. Miscellaneous Side-effects.- 6. Incompatibility.- 7. Physical Dependence and Withdrawal.- 8. Danger of Suicide.- VI. Thymoleptics.- A. Peripheral Effects.- B. Central Effects.- 1. Interaction with Central Autonomic Mechanisms.- 2. Effect on Behavior.- 3. Electrophysiologic Studies.- 4. Other Central Effects.- C. Metabolic Fate.- D. Adverse Reactions.- 1. Suicide and Poisoning.- 2. Central Nervous System.- 3. Peripheral Side-effects.- 4. Allergic Dermatoses.- 5. Agranulocytosis; Jaundice.- 6. Incompatibilities.- 7. Withdrawal Symptoms.- VII. Chemical Structures, General Clinical Use and Daily Human Rose Range of the most Frequently Used Psychotherapeutic Drugs.- Abbreviations.