This volume reviews the application of biochemical and molecular pathologies, which are based on conventional pathomorphology, toxicology, and DNA analysis technologies, not only to autopsies but also to the field of clinical medicine in general.

The systematic and integrated use of biochemical, immmunohistochemical, and molecular pathology, toxicology, DNA analysis, and cell culture investigations reinforces the pathophysiological diagnostic criteria in a forensic autopsy for clinical diagnosis. The use of these technologies can help to determine the cause and process of death and characterize the functional pathophysiological changes in the body that occur during the death process. Recently, the systematization of the latest supplemental tests, diagnostic methods, and quality control has allowed us to conduct comprehensive data collection and analysis for a range of diseases.

This book presents the latest findings on the pathology of a broad range of human diseases, based on data concerning postmortem biochemistry and molecular biology collected from approximately 1000 people. Further, it puts forward a code of ethics for undertaking pathophysiological research and describes research techniques for uncovering pathophysiological mechanisms. As such, it offers a unique resource for researchers in the field of forensic medicine and pathology, and for clinicians.

Autorentext
Prof. Dr. Takaki Ishikawa. M.D., Ph.D.
Department of Legal Medicine, Osaka City University Medical School

Inhalt

1. The ethics of medical practice.- 2. Forensic biochemistry.- 3. Application of molecular pathology to forensic medical diagnosis.- 4. Alcohol and pathophysiology.- 5. Forensic toxicology of methamphetamine and psychotropic drugs.- 6. Metabolic autopsy in sudden unexpected death.- 7. DNA analysis.- 8. Animal experiments in forensic science.- 9. Cultured cell experimental model.- 10. Future perspectives