Ernst Schering Research Foundation Workshop 23 Excitatory Amino Acids: From Genes to Therapy Editors: P. Seeburg, I. Bresink, L. Turski In this book emerging questions of current glutamate research are addressed and new pathways which glutamate research may take in the future discussed. Since glutamate antagonists are still the major hope for the therapy of neurodegenerative disorders in humans, research activities dedicated towards the development of such novel drugs are the focus of public attention. The book comments on the most recent discoveries in the field of neuroprotection and neurodegeneration.

Klappentext

In this book emerging questions of current glutamate research are addressed and new pathways which glutamte research may take in the future discussed. Since glutamate antagonists are still the major hope for the therapy of neurodegenerative disorders in humans, research activities dedicated towards the development of such novel drugs are the focus of public attention. The book comments on the most recent discoveries in the field of neuroprotection and neurodegeneration.

Inhalt

From the contents: Glutamate Receptor Channels, RNA Editing, and Epilepsy.- Regulation of Glutamate Receptor Gene Expression in Global Ischemia.- Factors Regulating Excitotoxic Neurodegeneration, The Role of Calcium and the Mitochondria.- Excitotoxicity, Genetics, and Neurodegeneration in Amyotrophic Lateral Sclerosis.- NO-NMDA Receptor Interactions, A Neuromolecular Approach to Novel Therapeutics.- Glutamate in Neurodegenerative Disorders, Phenotype Resulting from Decreased Expression of AMPA Receptor GluR-B Subunit mRNA in Rats.- Quantitative Estimation of NMDA Receptor-Mediated Calcium Entry in Central Neurons.- Calcium Permeability of Glutamate-Gated Channels in the CNS, Functional Role of the Calcium-Permeable AMPA Receptor Channels.- Localisation and Surface Expression of the AMPA Receptor Subunit GluR1 Using Green Fluorescent Protein and Anti-Peptide Antibodies.- Input- and Output-Specific Segregation of Amio Acid Neurotransmitter Receptors on the Surface of Central Neurones.