Essentials of Restenosis provides the practicing cardiologists and biologists an elaborate review of the current advances in the field. Authors explore the process of restenosis from bench to bedside, encompassing in equal detail the newest scientific findings of the biological mechanisms as well as the progression in development of diagnostics and treatments. The volume also provides the reader with a basic understanding of the biological process and the latest diagnostics and treatments of the disease, with an up-to-date detailed discussion of the most important recent findings.

Leading interventional cardiologists, including Patrick Serruys, Eric Topol, David Holmes, Thomas Luscher and others provide the gold-standard reference on the treatment of restenosis (coronary artery blockage) for interventional cardiologists. Dr. Serruys, who pioneered the use of drug-eluting stents, and other pioneers in the field cover everything from non-invasive imaging, to eluting stents, to brachytherapy through to the latest molecular biology-based treatments including antisense, stem cells and gene therapy, making this an essential reference for all interventional cardiologists. Thorough chapters discuss the current understanding on the pathophysiology, molecular and genetic base, and methods of diagnosis of restenosis, and present the current state-of-the-art management, including pharmacotherapy and interventional percutaneous approaches using brachytherapy, gene therapy and drug eluting stent technology.

All this makes Essentials of Restenosis an excellent handbook for introducing new intervention cardiologists, vascular biologists, and medical students into the subject. This text provides the reader with a complete overview of the basic and applied knowledge of restenosis, leading to better insight and decision-making in clinical practice.

Zusammenfassung
Leading interventional cardiologists, including Patrick Serruys, Eric Topol, David Holmes, Thomas Luscher and others provide the gold-standard reference on the treatment of restenosis (coronary artery blockage) for interventional cardiologists. Dr. Serruys, who pioneered the use of drug-eluting stents, and other pioneers in the field cover everything from non-invasive imaging, to eluting stents, to brachytherapy through to the latest molecular biology-based treatments including antisense, stem cells and gene therapy, making this an essential reference for all interventional cardiologists.

Inhalt
Pathophysiology and Diagnosis.- Unraveling the Complex Process of Restenosis From Bench to Bedside.- Epidemiology and Pathogenesis of Restenosis.- Clinical Presentation of Restenosis.- Pathological Anatomy of Restenosis.- The Influence of Shear Stress on Restenosis.- The Immune System in the Pathogenesis of Vascular Proliferative Disease.- Animal Restenosis Models.- Genetic Basis of Restenosis.- The Genomics of Restenosis.- Gene-Expression Profiling and Restenosis.- Proteomics and Restenosis.- Contribution of Circulating Progenitor Cells to Vascular Repair and Lesion Formation.- Cell Cycle Regulators and Vascular Proliferative Diseases.- Arterial Remodeling.- The Role of eNOS in Vascular Diseases.- Diagnosis of Restenosis.- The Use of Pressure Gradient in the Diagnosis of Restenosis.- The Use of Radio Isotopes in the Diagnosis of Vascular Proliferative Disease.- Magnetic Resonance Imaging for Restenosis.- Coronary Imaging With Multislice Spiral Computed Tomography.- Therapy of Restenosis.- Pharmacotherapy of Restenosis.- Brachytherapy.- Preclinical Data of Eluting Stents.- Clinical Data of Eluting Stents.- Biodegradable Stents.- Biotechnology in the Treatment of Restenosis.- Vascular Gene Therapy.- Antisense and ODN Transcription Factors in the Treatment of Vascular Proliferative Disease.- Cell Cycle Approaches to the Treatment of In-Stent Restenosis.- Local Gene and Cell Delivery Devices.