This book presents the best, peer-reviewed contributions from the XII Congress of the Italian Society of Ergonomics and Human Factors (SIE), held in Lucca, Italy, on May 2-4, 2022. By highlighting the latest theories and models, as well as cutting-edge technologies and applications, and by combining findings from a range of disciplines including engineering, design, robotics, management, computer science, human biology and behavioral sciences, it provides researchers and practitioners alike with a comprehensive, timely guide on human factors and ergonomics in a variety of industrial sectors, such as health care, transportation, automotive and constructions. It also offers an excellent source of innovative ideas to stimulate future discussions and developments aimed at applying knowledge and techniques to optimize system performance, while at the same time promoting health, safety, and well-being of individuals anc communities. The proceedings includes papers from researchers and practitioners, scientists and physicians, institutional leaders, managers, and policy makers that contribute to constructing the Human Factors and Ergonomics approach across a variety of methodologies, domains, and productive sectors.