During the past thirty years, great progress has been made in defining the roles of steroid, peptide, and polypeptide hormones in the processes of lung morphogenesis, differentiation of specialized cell types, and surfactant synthesis. In Endocrinology of the Lung, Carole Mendelson has assembled a panel of leading investigators to critically review the roles of various classes of endocrine, paracrine, and neuroendocrine factors in the regulation of lung development and surfactant production. Special attention is accorded the actions of glucocorticoids in lung branching morphogenesis and the synthesis of surfactant glycerophospholipids and proteins. Also extensively examined are the roles of cell-cell interactions and the elaboration of various growth factors and bioactive peptides in pulmonary cell differentiation, gene expression, and pathophysiology. The model systems utilized in these studies range from whole animal to transgenic and gene-targeted mice, to organ and cell culture. State-of-the-art and comprehensive, Endocrinology of the Lung constitutes a powerful new standard guide that illuminates the complex endocrinology of the lung for investigators actively studying hormone action in pulmonary biology and medicine today.

Klappentext

Carole Mendelson has assembled a panel of leading investigators to critically review the various classes of endocrine, paracrine, and neuroendocrine factors that play a role in the regulation of lung development and surfactant production. Special attention is accorded the actions of glucocorticoids in lung development and the synthesis of surfactant glycerophospholipids and proteins. Also extensively treated are the roles of cell-cell interactions and the elaboration of various growth factors and bioactive peptides in pulmonary cell differentiation, gene expression, and pathophysiology. State-of-the-art and comprehensive, Endocrinology of the Lung constitutes a powerful new standard guide that illuminates the complex endocrinology of the lung for all those actively investigating hormone action in pulmonary biology and medicine today.

Inhalt

The Glucocorticoid Domain in the Lung and Mechanisms of Action, Philip L. Ballard. Fetal Responses to Glucocorticoids, Alan H. Jobe and Machiko Ikegami. Cyclic Adenosine Monophosphate and Glucocorticoid Regulation of Surfactant Protein-A Gene Expression, Carole R. Mendelson, Laura F. Michael, Pampee P. Young, Jinxing Li, and Joseph L. Alcorn. Hormonal Regulation of Surfactant Protein-B and Surfactant Protein-C Gene Expression in Fetal Lung, Vijayakumar Boggaram. Glucocorticoid Regulation of Fatty Acid Synthase in Fetal Lung, Seamus A. Rooney. The Genetics of Glucocorticoid-Regulated Embryonic Lung Morphogenesis: A First Approximation of the Epigenetic Rules, Tina Jaskoll and Michael Melnick. Corticotropin-Releasing Hormone and the Lung, Maria Venihaki, Louis J. Muglia, and Joseph A. Majzoub. Sex Differences in Fetal Lung Development: Biology, Etiology, and Evolutionary Significance, Heber C. Nielsen and John S. Torday. Retinoids and Lung Development, Richard D. Zachman and Mary A. Grummer. Insulin and Lung Development, Jeanne M. Snyder, Thomas N. George, and Olga L. Miakotina. The Insulin-like Growth Factor System and Lung, Wayne A. Price and Alan D. Stiles. Platelet-Derived Growth Factor and Lung Development, Nicholas J. Cartel, and Martin Post. Transforming Growth Factor-b Receptor Signaling and Lung Development, Yun Zhao. Transgenic Mouse Models for the Study of Growth Factor Signaling During Lung Morphogenesis, Jeffrey A. Whitsett and Thomas R. Korfhagen. Parathyroid Hormone-Related Protein, Lewis P. Rubin and John S. Torday. Role of Neuroendocrine Cells in Fetal and Postnatal Lung, Mary E. Sunday and Ernest Cutz. Index.