Cancers of endocrine tissues are an increasingly important public health concern whose growing prevalence has made them the focus of intensive research in recent years. In Endocrine Oncology, Stephen P. Ethier and a panel of leading investigators comprehensively analyze the cellular, molecular, and endocrine factors involved in the development of cancers of the breast, prostate, endometrium, and ovary. Concentrating on defining the most important unresolved issues in the field, the authors review how steroid hormones function to regulate normal mammary gland homeostasis in humans, with particular emphasis on the roles of estrogen, progesterone, and growth factors. Also examined are the effects of steroids in prostate cancer development and treatment, the function of growth factors in endocrine neoplasia, the actions of such nonsteroid hormones as prolactin, and the role of the suppressor genes BRCA1 and BRCA2. Throughout the book, the clinical relevance of scientific findings is emphasized.
Comprehensive and up-to-date, Endocrine Oncology offers both basic and clinical
researchers not only the latest molecular and cellular findings on endocrine cancers, but also a powerful critical analysis that will prove invaluable to all endocrinologists and oncologists working in the area today.

Klappentext

Stephen P. Ethier and a panel of leading investigators comprehensively analyze the cellular, molecular, and endocrine factors in the development of cancers of the breast, prostate, endometrium, and ovary. Concentrating on defining the most important unresolved issues in the field, the authors review how steroid hormones function to regulate normal mammary gland homeostasis in humans, with particular emphasis on the roles of estrogen, progesterone, and growth factors. Comprehensive and up-to-date, Endocrine Oncology offers both basic and clinical researchers not only the latest molecular and cellular findings on endocrine cancers, but also a powerful critical analysis that will prove invaluable to all endocrinologists and oncologists working in the area today.

Inhalt

Estrogen Receptor in Mammary Gland Physiology, Elizabeth Anderson, Robert B. Clarke, and Anthony Howell. Multiple Facets of Estrogen Recptor in Human Breast Cancer, Leigh C. Murphy, Etienne Leygue, Helmut Dotzlaw, Amanda Coutts, Biao Lu, Aihua Huang, and Peter H. Watson. Progesterone Receptors in Normal and Neoplastic Breast, Rosemary L. Balleine, Patricia A. Mote, Sybille M. N. Hunt, Eileen M. McGowan, and Christine L. Clarke. Pathogenesis of Estrogen Receptor-Positive and -Negative Breast Cancer, Powel Brown, Suzanne Fuqua, and Craig Allred. Regulation of EGFR and ERBB2 Expression by Estrogen Receptor in Breast Cancer, Helen C. Hurst. Tamoxifen and Other Antiestrogens in Prevention and Therapy of Breast Cancer, Kathy Yao and V. Craig Jordan. Prolactin in Human Breast Cancer Development, Barbara K. Vonderhaar. Human Chorionic Gonadotropin in Breast Cancer Prevention, Jose Russo and I. H. Russo. Epidermal Growth Factor-Related Peptides in Endocrine Neoplasias, David S. Salomon, Caterina Bianco, Marta De Santis, Isabel Martinez-Lacaci, Christian Wechselberger, and Andreas D. Ebert. Insulin-Like Growth Factors and Endocrine Neoplasia, Douglas Yee and Adrian V. Lee. Insulin-Like Growth Factor Binding Proteins in Endocrine-Related Neoplasia, Giuseppe Minniti and Youngman Oh. Fibroblast Growth Factors and Their Receptors in Breast and Prostated Cancer, R. C. Coombes, S. Marsh, J. Gomm, and C. Johnston. Steroid Receptors in Prostate Cancer Development and Progression, Marco Marcelli, Nancy L. Weigel, and Dolores H. Lamb. Type I Family Growth Factor Receptors and Their Ligands in Prostate Cancer, K. E. Leverton and W. J. Gullick. Hormonal Manipulation of Prostate Cancer, Jeffrey M. Kamradt and Kenneth J. Pienta. Endocrinology of Epithelial Ovarian Cancer, Vicki V. Baker. Molecular Pathogenesis of Endometrial Cancer: The Role of Tamoxifen, Yukio Sonoda and Richard R. Barakat. Structure and Function of BRCA Genes, Kenneth L. van Golen and Sofia D. Merajver. Role of Apoptosisand Its Modulation by Bcl-2 Family Members in Breast and Prostate Cancer, Venil N. Sumantran, David R. Beidler, and Max S. Wicha. Transcriptional Coactivators in Cancer, Paul S. Meltzer. Index.