Strategies for the early diagnosis of Alzheimer's disease are among the most important and most discussed topics in dementia care today. In Early Diagnosis of Alzheimer's Disease, Drs. Leonard Scinto and Kirk Daffner provide a comprehensive survey of today's new diagnostic approaches to Alzheimer's disease. Leaders in the field critically survey the most promising clinical research on early diagnostic markers for Alzheimer's disease, including the elucidation of changes in the brain revealed by structural and functional neuroimaging, as well as the characteristic patterns of cognitive decline that are documented by sensitive neuropsychological tests, various genetic markers, and biological assays. In addition, there are reviews of current clinical practice in the diagnosis of Alzheimer's disease, the major theories about its pathophysiology, and the therapeutic and ethical implications of early diagnosis. Early Diagnosis of Alzheimer's Disease illuminates the complex issues surrounding the search for early markers of this highly prevalent disease. Addressed to clinicians caring for an aging population, researchers developing new therapeutics, and policymakers concerned about the impact of early diagnosis on the delivery of health care, this timely, state-of-the-art volume constitutes a new standard reference guide for all those working with Alzheimer's patients today.

Klappentext

Drs. Leonard Scinto and Kirk Daffner provide a comprehensive survey of new diagnostic approaches to Alzheimer's disease. The authoritative contributors critically survey the most promising current research on early diagnostic markers for Alzheimer's disease, including the elucidation of changes in the brain revealed by structural and functional neuroimaging, as well as the characteristic patterns of cognitive decline that are documented by sensitive neuropsychological tests, various genetic markers, and biological assays. Early Diagnosis of Alzheimer's Disease illuminates the complex issues surrounding the search for early markers of this increasingly widespread disease. It will establish a new standard reference guide for all those working with Alzheimer's patients.

Inhalt

Foreword, John C. Morris. Early Diagnosis of Alzheimer's Disease: An Introduction, Kirk R. Daffner and Leonard F.M. Scinto. Current Approaches to the Clinical Diagnosis of Alzheimer's Disease, Kirk R. Daffner. Pathological Diagnosis of Alzheimer's Disease, Changiz Geula. The Pathophysiology of Alzheimer's Disease, Dennis J. Selkoe. Genetic Testing the Early Diagnosis of Alzheimer's Disease, Deborah Blacker and Rudolph E. Tanzi. Structural Imaging Approaches to Alzheimer's Disease, Clifford R. Jack, Jr. and Ronald C. Petersen. Functional Imaging in Alzheimer's Disease, Reisa A. Sperling, Thomas A. Sandson, and Keith A. Johnson. Neuropsychological Detection of Early Probable Alzheimer's Disease, Dorene M. Rentz and Sandra Weintraub. Peripheral Markers of Alzheimer's Disease: Directions From the Alzheimer Pathogenic Pathway, Maire E. Percy, David F. Andrews, and Huntington Potter. Pupillary Response as a Possible Early Biological Marker for Alzheimer's Disease, Leonard F.M. Scinto. Implications of Early Diagnosis for the Development of Therapeutics for Alzheimer's Disease, David S. Knopman. An Ethical Context for Presymptomatic Testing in Alzheimer's Disease, Kenneth S. Kosik, Stephen G. Post, and Kimberly A. Quaid. Appendix. Index.