The Proceedings of the Eight International Symposium on Drugs Affecting Lipid Metabolism (8th D.A.L.M.) is the subject of this volume. Since the first symposium in 1960, each successive meeting has broken new ground in the field of pharmacological control of lipid levels - offering new and stimulating insights and exposing the audience to the state of the art. The field has progressed sufficiently to permit discussion of the cellular biology of athero­ sclerosis. The opening session was devoted to pathology, macrophages, lipoproteins and their receptors and choles­ terol ester metabolism. Because of the recent emergence of new apolipoprotein technology, a workshop devoted sole­ ly to apolipoprotein methodology was introduced followed by a plenary session devoted to their metabolism and structure. Another rapidly developing area of atherosclerosis research is non-invasive assessment of this condition. Accordingly, a session was devoted to new techniques for this research modality. The final plenary sessions were devoted to the roles of drugs and diet in athero~ scl~rosis - cause, treatment and mechanisms of action. The meeting was summarized by Dr. O.J. Pollak, one of the "founding fathers" of this field. There were nine sessions of proffered papers whose abstracts appear in this volume. In addition, special workshops (to be reported elsewhere) were devoted to several drugs including Oiyzanol, Probucol and Etofibrate.

Inhalt

Cellular Biology of Atherosclerosis.- The Cellular Pathobiology of Atherosclerosis in 1983.- Secretory Functions of the Mononuclear Phagocyte.- Risk Factors for the Development of Premature Cardiovascular Disease.- Fate of Cholesteryl Linoleyl Ether Injected into Rats as Chylomicrons, Acetylated LDL and HDL.- Hypertriglyceridemia: Lipoprotein Receptors and Atherosclerosis.- Hypertriglyceridemia and Atherosclerosis: Analysis of an Abnormal Lipoprotein System and Potential Beneficial Effects of Triglyceride Lowering Therapy.- Apolipoproteins.- The Role of Hydrophobicity in the Structure of the Human Plasma Lipoproteins.- Metabolism of Apolipoproteins and the Metabolic Heterogeneity of Apo B in the Rat.- Proapolipoprotein A-I Metabolism in the Human and the Rat.- Isolation and Characterization of the Apolipoprotein Genes.- Apoprotein Measurements.- Use of Monoclonal Antibodies in Studies of Lipoprotein Structure and Function.- Apolipoprotein E: Receptor Binding Properties.- Apolipoprotein E Mutants, Hyperlipidemia and Arteriosclerosis.- Noninvasive Assessment of Atherosclerosis.- Noninvasive Assessment of Atherosclerosis in Nonhuman Primates.- Noninvasive Assessment of Atherosclerosis: Studies in Man.- Noninvasive Atherosclerosis Assessment for Controlled Clinical Trials.- Drugs and Diet.- Strategy, Yield and Risks of Controlling Plasma Lipids in the Primary Prevention of Coronary Heart Disease.- Mechanisms of Action of Absorbable Hypolipidemic Drugs.- Dietary Factors Affecting Lipoprotein Metabolism.- Inhibition of Cholesterol Absorption by Natural Products.- Effects of Nicotinic Acid and Its Derivatives on Lipid Metabolism and Other Metabolic Factors Related to Atherosclerosis.- HMG-CoA Reductase Inhibitors.- The Role of Phosphorylation/Dephosphorylation in the Regulation of Cholesterol 7?-Hydroxylase Activity.- Calcium Antagonists and Atherosclerosis.- Management of Adherence to Prescribed Medication.- Meeting Summary.- Abstracts.- Abstracts.- Author Index.