Resistance to treatment represents the final common outcome for far too many patients with cancer. Even our most promising new drugs fall victim to drug resistance. Hormones and newer biological therapies, though safe and active, also lose their activity over time. In this volume of Drug Resistance, leading investigators in the field have reviewed the most basic mechanisms of drug resistance, and have proposed ways to modulate resistance. This comprehensive volume should be of value for basic and clinical scientists who wish to delve more deeply into this intriguing problem in the laboratory and devastating problem in the clinic.

Inhalt

Introduction. I: Membrane Transport Mechanism. 1. P-Glycoprotein- Mediated Multidrug Resistance: Experimental and Clinical Strategies for its Reversal; J.M. Ford, et al. 2. Multidrug Resistance Associated with Overexpression of MRP; S.P.C. Cole, R.G. Deeley. II: Resistance to Alkylating Agents. 3. Mechanisms of Resistance to Alkylating Agents; P.G. Penketh, et al. 4. Glutathione S-Transferases; A. Raha, K.D. Tew. 5. The Role of DNA Repair in Resistance to Drugs that Alkylate O6 of Guanine; O.N. Koç. III: Resistance to Microtubule Active Drugs. 6. Paclitaxel (TAXOL) Mechanisms of Resistance; A.M. Casazza, C.R. Fairchild. IV: Resistance to Anti-Metabolics. 7. Mechanisms of Clinical Resistance to 5-Fluorouracil Chemotherapy; E. Chu, C.J. Allegra. 8. Antifolates: The Next Generation; E.A. Rayl, G. Pizzorno. 9. Human Immunodeficiency Virus Replication in the Presence of Antiretroviral Drugs: Analogies to Antineoplastic Drug Resistance; R.K. Strair, D.J. Medina. V: Topoisomerases. 10. Cellular Resistance to Topoisomerase Poisons; E.H. Rubin, et al. VI: Resistance to Endocrine Therapies. 11. The Acquisition of an Antiestrogen Resistant Phenotype in Breast Cancer: The Role of Cellular and Molecular Mechanisms; R. Clarke, et al. 12. Androgen Receptor Mutations in Prostate Cancer; E.P. Gelmann. VII: Resistance to Retinoids. 13. Retinoids in Clinical Cancer Therapy; J.R.F. Muindi. VIII: NovelMechanisms and Approaches. 14. Apoptosis and Cancer Chemotherapy; S. Lutzker, A.J. Levine. 15. The Interaction of Chemotherapy and Biological Response Modifiers in the Treatment of Melanoma; A.C. Buzaid, C.M. Anderson, E.A. Grimm. 16. Multifunctional Modulators of Drug Resistance; J.R. Murren, et al. Index.