A major difficulty in successfully treating cancer with drugs is achieving adequate drug concentrations in the diseased areas without overexposing drug-sensitive normal tissues. In a number of cases, specialized drug delivery systems are required to realize a therapeutic gain. In Drug Delivery Systems in Cancer Therapy, Dennis M. Brown has assembled a panel of leading experts to survey all the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. They also profile the use of novel formulation technologies-including synthetic polymers and biomaterials for sustained drug release to achieve greater therapeutic effect-that have demonstrated efficacy in a number of approved and late-stage clinical products. They also consider the benefits of, and future opportunities for, various drug delivery systems, as well as the experimental techniques used in their evaluation. Although the focus is primarily on small molecule delivery, many of the technologies described can also be effective in delivering larger biomolecules.
Comprehensive, cutting-edge, and highly practical, Drug Delivery Systems in Cancer Therapy captures for experimental oncologists, medicinal chemists, and pharmacologists the universe of approaches, technologies, and systems available for substantially enhancing the therapeutic outcome of anticancer drug delivery today.

Klappentext

Leading experts survey the currently available technologies designed to improve the delivery of today's cancer chemotherapeutic agents. The authors review both the theoretical and practical considerations governing conventional and nonconventional methods of drug administration, and identify promising opportunities for product development. In their outline and discussion of the use of novel formulation technologies-including synthetic polymers and biomaterials for prolonged or sustained drug release to achieve potentially greater therapeutic effect-they profile those technologies that have resulted in a number of approved and late-stage clinical products.

Inhalt

Part I: Pharmacological Considerations for Drug Delivery Systems in Cancer Medicine Systemically Administered Drugs Reginald B. Ewesuedo and Mark J. Ratain Regional Administration of Antineoplastic Drugs Maurie Markman Theoretical Analyses and Simulations of Anticancer Drug Delivery Ardith W. El-Kareh and Timothy W. Secomb Part II: Technologies Available for Use in Cancer Drug Delivery Systems Biopolymers for Parenteral Drug Delivery in Cancer Treatment Wolfgang Friess Hydrogels in Cancer Drug Delivery Systems Sung-Joo Hwang, Namjin Baek, Haesun Park, and Kinam Park Microparticle Drug Delivery Systems Duane T. Birnbaum and Lisa Brannon-Peppas Polyethylene Glycol Conjugation of Protein and Small Molecule Drugs: Past, Present, and Future Robert G. L. Shorr, Michael Bentley, Simon Zhsao, Richard Parker, and Brendan Whittle Emulsions As Anticancer Delivery Systems S. Esmail Tabibi Part III. Current Applications: Products Approved or in Advanced Clinical Development Liposomal Drug Delivery Systems for Cancer Therapy Daryl C. Drummond, Dmitri Kirpotin, Christopher C. Benz, John W. Park, and Keelung Hong Gliadel®: A New Method for the Treatment of Malignant Brain Tumors Francesco DiMeco, Henry Brem, Jon D. Weingart, and Alessandro Olivi Intralesional Chemotherapy with Injectable Collagen Gel Formulations Elaine K. Orenberg Sustained-Release Drug Delivery with DepoFoam Sankaram B. Mantripragada and Stephen B. Howell Cancer Vaccines Susanne Osanto Part IV. Future Directions: Novel Cancer Drug Targets and Delivery Systems Gene Therapy of Cancer Susanne Osanto Progress in Antisense Technology Stanley T. Crooke Tumor Vaccines Francesco M. Marincola Diagnosis and Treatment of HumanDisease Using Telomerase As a Novel Target Lynne W. Elmore and Shawn E. Holt Index