Most biological pathways, physical and neurological properties are highly conserved between humans and Drosophila and nearly 75% of human disease-causing genes have a functional homologue in Drosophila. This volume provides recent advances in Drosophila models for various human diseases, with each chapter providing a review of studies involving Drosophila models, as well as detailed protocols commonly used in laboratories. Starting with a review of Drosophila's value as a highly tractable model organism for studying human diseases, subsequent chapters present Drosophila models for specific human diseases.The book provides a useful resource for all scientists who are starting to use the Drosophila model in their studies, and for researchers working in the pharmaceutical industry and using new screening models to develop new medicines for various diseases.

Autorentext

Masamitsu Yamaguchi received his PhD from Osaka University and is currently a Professor of Applied Biology, Kyoto Institute of Technology. He is a former director of the Advanced Insect Research Promotion Center at Kyoto Institute of Technology.

Inhalt

Ch1 Drosophila as a model organism

Masamitsu Yamaguchi, Hideki Yoshida, Department of Applied Biology, Kyoto Institute of Technology

Ch2 Adult intestine aging model

Takashi Okumura, Koji Takeda, Takashi Adachi-Yamada, Gakushuin University

Ch3 Alzheimer's disease model

Leo Tsuda, National Center for Geriatrics and Gerontology (NCGG)

Ch 4 Parkinson's disease model Dang Thi Phuong Thao, University of Science, Vietnam National University, Ho Chi Minh City

Chapter 5

Repeat expansion disease model

Morio Ueyama, Yoshitaka Nagai, Osaka University

Ch6 Amyotrophic lateral sclerosis model Yumiko Azuma, Takahiko Tokuda, Kyoto Prefectural University of Medicine

Ch7 Charcot-Marie-Tooth disease model

Masamitsu Yamaguchi, Hiroshi Takashima, Kyoto Institute of Technology, Kagoshima University

Ch8 Role of long non-coding RNA in neurological diseases

Luca Lo Piccolo, Kyoto Institute of Technology

Ch9 Muscular dystrophy model

Saranyapin Potikanond, Wutigri Nimlamool, Jasprien Noordermeer, Lee Fradkin

Chiang Mai University, Molecular biology department, Leiden University Medical Center (LUMC), Department of Neurobiology, UMass Medical School

Ch10 Cancer model

Tatsushi Igaki, Kyoto University

Ch11 Leukemia model

Lucas Waltzer, Centre de Biologie du Développement, CNRS Université Paul Sabatier, Toulouse, France

Ch12 Diseases of replication /repair genes

Sue Cotterill, St Georges University of London

Ch13 Drosophila models for studying UPR in insulin-like peptide producing cells and onset of type I diabetes

Yoshihiro H. Inoue, Insect Biomedical Research Center, Kyoto Institute of Technology

Ch14 Metabolomics study on Drosophila models

Phan Nguyen Thuy An, Eiichiro Fukusaki, Graduate School of Engineering, Osaka University

Ch15 Humanized flies for functional analysis of the human genome and cross-species comparison

Toshiyuki Takano-Shimizu, Department of Drosophila Genomics and Genetic Resources, Kyoto Institute of Technology

Ch16 Designs for Flies

Frank Kolkman, Julia Cassim, Royal College of Arts, Kyoto Institute of Technology