This book is a comprehensive review of the detailed molecular mechanisms of and functional crosstalk among the replication, recombination, and repair of DNA (collectively called the "3Rs") and the related processes, with special consciousness of their biological and clinical consequences. The 3Rs are fundamental molecular mechanisms for organisms to maintain and sometimes intentionally alter genetic information. DNA replication, recombination, and repair, individually, have been important subjects of molecular biology since its emergence, but we have recently become aware that the 3Rs are actually much more intimately related to one another than we used to realize. Furthermore, the 3R research fields have been growing even more interdisciplinary, with better understanding of molecular mechanisms underlying other important processes, such as chromosome structures and functions, cell cycle and checkpoints, transcriptional and epigenetic regulation, and so on. This book comprises 7 partsand 21 chapters: Part 1 (Chapters 1-3), DNA Replication; Part 2 (Chapters 4-6), DNA Recombination; Part 3 (Chapters 7-9), DNA Repair; Part 4 (Chapters 10-13), Genome Instability and Mutagenesis; Part 5 (Chapters 14-15), Chromosome Dynamics and Functions; Part 6 (Chapters 16-18), Cell Cycle and Checkpoints; Part 7 (Chapters 19-21), Interplay with Transcription and Epigenetic Regulation. This volume should attract the great interest of graduate students, postdoctoral fellows, and senior scientists in broad research fields of basic molecular biology, not only the core 3Rs, but also the various related fields (chromosome, cell cycle, transcription, epigenetics, and similar areas). Additionally, researchers in neurological sciences, developmental biology, immunology, evolutionary biology, and many other fields will find this book valuable.

Inhalt

Part 1 DNA Replication.- 1 Molecular Mechanism of DNA Replication.- 2 Characteristics of Metazoan DNA Replication Origins.- 3 DNA Replication Timing: Temporal and Spatial Regulation of Eukaryotic DNA Replication.- Part 2 DNA Recombination.- 4 Mechanism of Homologous Recombination.- 5 Regulation of Recombination by Chromatin.- 6 Homologous Recombination During Meiosis.- Part 3 DNA Repair.- 7 DNA Damage Recognition and Repair in Mammalian Global Genome Nucleotide Excision Repair.- 8 The Fanconi Anemia Pathway and Interstrand Crosslink Repair.- 9 The Crossroads of Ubiquitination and DNA Repair: A Structural Perspective.- Part 4 Genome Instability and Mutagenesis.- 10 Genome Instability of Repetitive Sequence: Lesson From the Ribosomal RNA Gene Repeat.- 11 Translesion DNA Synthesis and Damage Tolerance Pathways.- 12 Mismatch Repair.- 13 Non-Homologous End-Joining.- Part 5 Chromosome Dynamics and Functions.- 14 Centromeric Chromatin and Kinetochore Assembly in Vertebrate Cells.- 15 CST Complex and Telomere Maintenance.- Part 6 Cell Cycle and Checkpoints.- 16 Signaling of DNA Replication Stress Through the ATR Checkpoint.- 17 Spindle Assembly Checkpoint: Its Control and Aberration.- 18 Molecular Insights Into the Regulation of Apoptosis and Cellular Senescence and Their Implications for Cancer.- Part 7 Interplay with Transcription and Epigenetic Regulation.- 19 DNA Replication and Histone M odification.- 20 Establishment and Maintenance of DNA Methylation.- 21 Active DNA Demethylation in Development, Human Disease, and Cancer.- BM Index.