This book constitutes the refereed proceedings of the 25th International Conference on Distributed Computer and Communication Networks, DCCN 2022, held in Moscow, Russia, in September 2022. The 27 full papers and 2 short papers included in this book were carefully reviewed and selected from 130 submissions. They were organized in topical sections as follows: Distributed Systems Applications, Computer and Communication Networks, Analytical Modeling of Distributed Systems.