While sales of dietary supplements have skyrocketed in recent years, information about their safety and efficacy in humans is generally sparse in comparison with what is available for prescription drugs. Dietary Supplements: Toxicology and Clinical Pharmacology presents, in both comprehensive and summary formats, a wealth of objective information for a selection of significant nonherbal dietary supplements. The supplements detailed were chosen for their popularity, toxicity, and the quantity and quality of information available, and include such well-known agents as DHEA,
androstenedione and other over-the-counter steroids, coenzyme Q10, fish oil, glucosamine and chondroitin, chitosan, chromium picolinate, creatine, vanadyl sulfate, SAMe, and melatonin. Additional coverage is given to colloidal silver, shark cartilage, germanium, red yeast rice extract, l-tryptophan, N,N-dimethylglycine, GHB and GBL, huperzine, hydrazine, methylsulfonylmethane, and pyruvate. Each monograph discusses the history of the compound; its chemical structure; its current and promoted uses, sources, and chemical composition; and its toxicity, pharmacokinetics, and physiological role. Also presented are case reports of their adverse effects and interactions, as well as information on their reproductive effects, chemical and biofluid analysis, and regulatory status. Each chapter is based on original studies published in reputable peer-reviewed journals, as well as on meta-analyses, systematic reviews, or other high-quality assessments by recognized experts.
Authoritative and objective, Dietary Supplements: Toxicology and Clinical Pharmacology offers physicians, pharmacologists, pharmacists, toxicologists, and medical examiners a treasure trove of uncommon-but reliable-scientific and clinical information on the toxicity and usefulness of today's leading nonherbal dietary supplements.

Klappentext

A treasure trove of uncommon and reliable scientific and clinical information for the toxicity and usefulness of today's leading nonherbal dietary supplements. The supplements detailed were chosen for their popularity, toxicity, and the quantity and quality of information available. Each monograph discusses the history of the compound; its chemical structure; its current and promoted uses, sources, and chemical composition; and its toxicity, pharmacokinetics, and physiological role. Also presented are case reports of adverse effects and interactions, as well as information on reproductive effects, chemical and biofluid analysis, and regulatory status. Each chapter is based on original studies published in reputable peer-reviewed journals, as well as on meta-analyses, systematic reviews, or other high-quality assessments by recognized experts.

Inhalt

Part I. Legal/Regulatory Aspects of Dietary Supplements Chapter 1. Legal/Regulatory Aspects of Dietary Supplements Melanie Johns Cupp. Summary Part II. Monographs Chapter 1. Androstenedione and Other Over-the-Counter Steroids Jason L. Duncan, Melanie Johns Cupp, and Timothy S. Tracy History Chemical Structure Current Promoted Uses Sources and Chemical Composition Products Available. Physiologic Role Clinical Studies Pharmacokinetics Adverse Effects and Toxicity Interactions Reproduction Chemical and Biofluid Analysis Regulatory Status Summary Chapter 2. Chitosan Kimberly Novak, Melanie Johns Cupp, and Timothy S. Tracy History Chemical Structure Current Promoted Uses Sources and Chemical Composition Products Available Animal Data Clinical Studies Pharmacokinetics Adverse Effects and Toxicity Interactions Reproduction Chemical and Biofluid Analysis Regulatory Status Summary Chapter 3. Chromium Picolinate Aleshia R. Haslacker, Melanie Johns Cupp, and Timothy S. Tracy History Chemical Structure Current Promoted Uses Sources and Chemical Composition Products Available Animal Data Clinical Studies Lipid Levels Body Composition and Strength Diabetes Pharmacokinetics Adverse Effects and Toxicity Interactions. Reproduction Biofluid Analysis Regulatory Status Summary Chapter 4. Coenzyme Q10 (Ubiquinone, Ubidecarenone) Melanie Johns Cupp and Timothy S. Tracy History Chemical Structure Current Promoted Uses Sources and Chemical Composition Products Available Physiologic Role In Vitro Effects and Animal Data Clinical Studies Heart Failure Heart Surgery Hypertension Cancer Doxorubicin-InducedCardiotoxicity Hyperlipidemia Diabetes Exercise Capacity Myopathies Periodontal Disease Photoaging Sperm Function Primary Biliary Cirrhosis Immune Function Chronic Fatigue Syndrome Huntington's Disease Migraine Pharmacokinetics Adverse Effects and Toxicity Interactions Reproduction Chemical and Biofluid Analysis Regulatory Status Summary Chapter 5. Colloidal Silver Melanie Johns Cupp and Timothy S. Tracy History Chemical Structure Current Promoted Uses Sources and Chemical Composition In Vitro Effects Clinical Data Adverse Effects and Toxicity Interactions Reproduction Chemical and Biofluid Analysis Regulatory Status Summary Chapter 6. Creatine Monohydrate Nancy Romanchak, Melanie Johns Cupp, and Timothy S. Tracy History Chemical Structure Current Promoted Uses Sources and Chemical Composition Products Available Physiologic Role In Vitro Effects and Animal Data Clinical Studies Inborn Errors of Metabolism Enhancement of Athletic Performance Cardiovascular Effects Pharmacokinetics Adverse Effects and Toxicity Interactions Reproduction Chemical and Biofluid Analysis Regulatory Status Summary Chapter 7. Dehydroepiandrosterone (DHEA) (Prasterone) John Edward Pope, Melanie Johns Cupp, and Timothy S. Tracy History Chemical Structure Current Promoted Uses Sources and Chemical Composition Products Available Physiologic Effects In Vitro Effects and Animal Data Clinical Studies Exercise Performance Systemic Lupus Erythematosus Replacement in Aging Depression HIV/AIDS Other Clinical Studies Pharmacokinetics Adverse Effects and Toxicity Interactions Reproduction Chemical and Bio