This book provides an overview of pulmonary hypertensive diseases, the current understanding of their pathobiology, and a contemporary approach to diagnosis and treatment. It discusses the definition and classification of these disorders and the epidemiology of pulmonary arterial hypertension (PAH); explores the approach to diagnosis and evaluation via methods such as echocardiography, right heart catheterization, and cardiopulmonary exercise testing; describes the major drug classes used to treat PAH and the cell signaling pathways that they target as well as adjunct and investigative therapies; and highlights special situations that are particularly challenging in the management of PAH. Written by experts in their respective fields, Diagnosis and Management of Pulmonary Hypertension is a valuable resource for pulmonologists, cardiologists, and practitioners in internal medicine and critical care.

Autorentext
James R. Klinger, MD is a graduate of the Medical College of Wisconsin, Milwaukee, WI. He performed his residency at the Medical College of Pennsylvania, Philadelphia, PA and fellowship at Rhode Island Hospital and Brown University School of Medicine in pulmonary and critical care medicine. He is licensed and certified in internal medicine and critical care medicine. His teaching role includes being a lecturer in pulmonary pathophysiology as well as extensive hospital teaching roles at Rhode Island Hospital for house staff and pulmonary fellows. Klinger's numerous publications can be viewed in Chest, the Journal of Applied Physiology, American Journal of Respiratory Critical Care Medicine, American Journal of Medicine, and many more. His research concerns development of therapies to treat pulmonary hypertension as well as research in the field of blood clotting, which can be one cause of pulmonary hypertension. Klinger is an active speaker and expert in the field of pulmonary hypertension and has many speaking engagements across the country.

Inhalt

The Pulmonary Circulation.- Epidemiology and Disease Classification of Pulmonary Hypertension.- Pathogenesis of Pulmonary Arterial Hypertension.- Hypoxic Pulmonary Hypertension.- Pulmonary Hypertension In Chronic Heart And Lung Disease.- Chronic Thromboembolic Pulmonary Hypertension.- Schistosomiasis- Associated Pulmonary Arterial Hypertension.- Approach to the Patient with Elevated Pulmonary Arterial Pressure.- Echocardiography.- Pulmonary Hemodynamics and Right Heart Catheterization.- Cardiopulmonary Exercise Testing in Pulmonary Hypertension.- Adjunct Therapy and Calcium Channel Blockers.- Prostacyclin Therapy for Pulmonary Arterial Hypertension.- Endothelin Receptor Antagonists.-Modulation Of cGMP Synthesis And Metabolism.- Combination Therapy for the Treatment of Pulmonary Arterial Hypertension.- Investigative Therapies in Pulmonary Arterial Hypertension.- Pulmonary Hypertension In Critically Ill Patients.- Perioperative Management of Pulmonary Hypertension.