With over ten million diagnosed patients and another five million undiagnosed, diabetes mellitus and its complications-cardiovascular disease, nephropathy, neuropathy, and retinopathy-is a major public health problem that will assume epidemic proportions as the population grows older. In Diabetes and Cardiovascular Disease, Michael T. Johnstone, md, and Aristidis Veves, md, dsc, have assembled a panel of seasoned clinicians and expert scientists to comprehensively review both the clinical and scientific aspects of diabetic cardiovascular disease. The contributors thoroughly discuss the mechanisms and risk factors of diabetes in relation to hypertension, dyslipidemia, thrombosis, atherosclerosis, coronary artery disease, and congestive heart failure. Their review includes a full examination of the epidemiology, mechanisms, methods of assessment, and treatment of the disease at the macrovascular level, and a discussion of its microvascular effects, including retinopathy, nephropathy, neuropathy, and compromised microcirculation in the diabetic foot. Each chapter covers its topics in great detail and is accompanied by extensive references.
Comprehensive and up-to-date, Diabetes and Cardiovascular Disease offers not only practicing physicians the day-to-day practical knowledge needed to treat patients effectively, but also clinical scientists a deeper understanding for developing novel therapies for this devastating illness.

Klappentext

Zur Zeit liegt uns keine Inhaltsangabe vor.

Inhalt

Part I. Pathophysiology The Metabolic Syndrome and Vascular Disease Aresh J. Anwar, Anthony H. Barnett, and Sudhesh Kumar Effects of Insulin on the Vascular System Helmut O. Steinberg Effect of Diabetes on Endothelial Function Keiko Naruse and George L. King Vascular Abnormalities in the Prediabetic State Enrique Caballero, Su Chi Lim, Edward S. Horton, and Aristidis Veves Diabetes and Advanced Glycation End Products Helen Vlassara The Renin-Angiotensin System in Diabetic Cardiovascular Complications Edward P. Feener Diabetes and Hypertension James R. Sowers Diabetes and Dyslipidemia Henry N. Ginsberg and Catherine Tuck Diabetes and Thrombosis David J. Schneider and Burton E. Sobel Diabetes and Atherosclerosis Maria F. Lopes-Virella Animal Models of Diabetes and Atherosclerosis Peter D. Reaven and Wulf Palinski Nitric Oxide and Its Role in Diabetes Mellitus Michael T. Johnstone and Todd A. Caulfield Plasminogen Activator Inhibitor-1 and Vascular Disease in Diabetes Mellitus Douglas E. Vaughan Part II. The Heart Coronary Artery Disease in Diabetes Doron Aronson and Michael T. Johnstone Heart Failure in Diabetic Patients Lawrence H. Young, Raymond R. Russell, III, Deborah Chyun, and Tarik Ramahi Preoperative Assessment and Perioperative Management of the Surgical Patient with Diabetes Mellitus Theodoros Laddis and Mylan C. Cohen Part III. Peripheral Vascular System Epidemiology of Peripheral Vascular Disease Edward J. Boyko, Nicholas L. Smith, and Jessie H. Ahroni Diabetes and Arterial Stiffness Ian B. Wilkinson, Jukka Westerbacka, Hannele Yki-Jarvinen, and John R. Cockcroft Methods for Assessing Large Vessel Pathophysiology Rola Saouaf Peripheral Vascular Disease in Patients with Diabetes Mellitus Allen D. Hamdan, Frank B. Pomposelli, Jr., Gary W. Gibbons, and Frank W. LoGerfo Part IV. Microcirculation Diabetic Retinopathy Lloyd Paul Aiello and Jerry Cavallerano Diabetes and Nephropathy Bijan Roshan and Richard J. Solomon Vascular Changes and Diabetic Neuropathy Rayaz A. Malik, Solomon Tesfaye, and John D. Ward Microcirculation of the Diabetic Foot Osama Hamdy, K. Abuelenin, and Aristidis Veves